Evidence map›Paper›PMID 42156922›Full record

ArticleCommunications biology2026

The cellular correlates and adolescent reorganisation of cortical myelination networks in the common marmoset.

E D Hutchings, S J Sawiak, R L Smith, R A I Bethlehem, A C Roberts, E T Bullmore

Abstract read
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

E D HutchingsDepartment of Psychiatry, University of Cambridge, Cambridge, UK. eh636@cam.ac.uk.ORCID http://orcid.org/0009-0007-4534-7170
S J SawiakDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-4210-9816
R L SmithDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
R A I BethlehemDepartment of Psychology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-0714-0685
A C RobertsDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-2873-157X
E T BullmoreDepartment of Psychiatry, University of Cambridge, Cambridge, UK.

Funding

Rosetrees Trust MB2023\100002
6 · The paper itself

Abstract

Structural similarity provides a powerful framework for measuring coordinated macro- and micro-structural variation across the cortex of a single brain. Similarity networks derived from myelin-sensitive MRI sequences undergo marked reorganisation during adolescence, linked to adversity exposure and behavioural outcomes in humans and rodents. However, the cellular mechanisms of MRI similarity and its development in non-human primate cortex remain unexplored. Here, we use myelin-sensitive T1w/T2w ratio images from a cross-sectional sample of 446 common marmosets (aged 0.62 to 12.75 years) to estimate MIND (Morphometric INverse Divergence) as a measure of myelination similarity in individual animals. We find that MIND metrics of myelination similarity are highly correlated with spatial gene expression of myelin basic protein (MBP) and other genes enriched in glutamatergic neurons and PV+ and VIP+ interneurons, reflecting the activity dependence of myelination. Across adolescence, network phenotypes accurately predict animal age and reproducibly capture an axis of myeloarchitectonic maturation spanning primary to transmodal association cortices, consistent with patterns observed in humans. Similarity mapping is a biologically validated and technically reliable measure of cortical myelination networks that can advance our understanding of phylogenetically conserved patterns of myelination network development in the marmoset cortex.

Indexed as

CallithrixCerebral CortexMyelin SheathAnimalsFemaleMagnetic Resonance ImagingMaleMyelin Basic ProteinMyelin Basic Protein

Identifiers

PMID42156922
PMCPMC13454510

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.