Evidence map›Paper›PMID 42156880›Full record

ArticleScientific reports2026

Metabolic impairments in peripheral blood mononuclear cells after BNT162b2 vaccination in liver transplantation adolescents.

Supranee Buranapraditkun, Nakarin Kitkumthorn, Arkom Chaiwongkot, Pattarawat Thantiworasit, Palittiya Sintusek

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Supranee BuranapraditkunDivision of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand. supranee.b@chula.ac.th.
Nakarin KitkumthornFaculty of Dentistry, Burapha University, Chonburi, 20131, Thailand.
Arkom ChaiwongkotDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Pattarawat ThantiworasitKing Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, 10330, Thailand.
Palittiya SintusekCenter of Excellence in Thai Pediatric Gastroenterology, Hepatology and Immunology (TPGHAI), Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.

Funding

The Thailand Science Research and Innovation Fund Chulalongkorn University HEA663000048
6 · The paper itself

Abstract

The mRNA vaccine BNT162b2 was approved to prevent COVID-19 disease in adolescents. Currently, there are no data on cellular metabolism in adolescents receiving liver transplantation (LT) before and after SARS-CoV-2 vaccination. This study aimed to investigate the effects of the BNT162b2 mRNA vaccine on cellular metabolism in LT adolescents compared to healthy adolescents. The bioenergetics study was performed using the PBMCs of 15 LT adolescents and 15 healthy adolescents aged between 12 and 18 years. All participants received 30 µg of BNT162b2 on days 0 and 21. Blood samples were collected at 3 time points: before vaccination (day 0), on day 21 and on day 35 after the first dose. Mitochondrial respiration and glycolysis in the frozen PBMCs were measured by using a Seahorse XFp analyzer. The results showed that LT adolescents had a lower oxygen consumption rate (OCR) during mitochondrial respiration than healthy adolescents at all time points. Additionally, LT adolescents exhibited reduced glycolysis, as indicated by a lower extracellular acidification rate (ECAR), throughout the study period. These findings suggest that impairments in mitochondrial and glycolytic metabolism observed in PBMCs from LT adolescents after BNT162b2 vaccination may contribute to the early suppression of the immune response. Future studies should evaluate which immune cells are critical for metabolic dysfunctions.

Indexed as

Leukocytes, MononuclearLiver TransplantationAdolescentBNT162 VaccineChildFemaleGlycolysisHumansMaleMitochondriaOxygen ConsumptionVaccinationBNT162 VaccineAdolescentsBNT162b vaccineCellular metabolismLiver transplantationPeripheral blood mononuclear cellsSeahorse XFp analyzer

Identifiers

PMID42156880
PMCPMC13385713

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.