Construction of a risk prediction model for multiple bronchoalveolar lavages in children with necrotizing pneumonia based on LASSO regression.

Zewen Ding, Jiapu Hou, Ruiyang Sun, Wanyu Jia, Peng Li, Shuqin Fu, Chunlan Song

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Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Zewen DingHenan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.

Jiapu HouHenan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.

Ruiyang SunHenan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.

Wanyu JiaHenan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.

Peng LiHenan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.

Shuqin FuHenan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.

Chunlan SongHenan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China. 13526867323@163.com.

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6 · The paper itself

Abstract

backgroundTo explore the risk factors for multiple bronchoalveolar lavages in children with necrotizing pneumonia (NP) and construct a prediction model.

methodsTo analyze the clinical data of patients with NP from January 2019 to June 2025, and divided into a Single- Bronchoalveolar lavage (BAL) group and Multiple-BAL group, analyze and construct the model.

resultsThe single-BAL group had 139 patients, the multiple-BAL group 196. The incidence of sputum plug obstruction and bronchial erosion with necrosis was greater in the multiple-BAL group (P < 0.05). The platelet distribution width (PDW), lactate dehydrogenase (LDH) in the multiple-BAL group were greater (P < 0.05). Sputum plug obstruction, bronchial mucosal erosion and necrosis with softening, fibrinogen (FIB) < 2.84 g/L, PDW > 9.5%, and LDH > 576 U/L are risk factors for multiple alveolar lavages in pediatric patients with NP. The combined model had an AUC of 0.801, indicating good discrimination. The combined model showed good predictive performance after Bootstrap validation.

conclusionsThe presence of sputum plug obstruction, bronchial mucosal erosion and necrosis with softening, FIB < 2.84 g/L, PDW > 9.5%, and LDH > 576 U/L are risk factors for multiple bronchoalveolar lavages in pediatric patients with NP. IMPACT: Identified 5 risk factors for multiple-BAL in pediatric NP, and built a quantifiable guiding model. Fills the gap of no multiple-BAL criteria in pediatric NP, integrating pathology and hematological indicators. Optimizes treatment, reduces burden, and facilitates clinical standardization.

Identifiers

PMID42156862

DOI10.1016/j.resp.2020.103562

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