ArticleScientific reports2026
IL-1β alleviates suppressive potential of bone marrow mesenchymal stem cells in macrophage M1 polarization via autophagy mediated degradation of SPP1.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
The immunomodulatory properties of mesenchymal stem cells (MSCs) are often influenced by inflammatory microenvironment. However, the specific effects of IL-1β on immunomodulatory role of bone marrow derived MSCs (BMSCs) remain need to be understood. In this study, the role of autophagy induced by IL-1β contributes to immunoregulatory effect of BMSCs on macrophage polarization was investigated. We isolated and characterized BMSCs through morphological analysis, flow cytometry, and differentiation potential. Interleukin 1β (IL-1β) was employed to stimulate BMSCs in vitro. Secreted phosphoprotein 1 (SPP1) expression, autophagy and MAPK signaling in BMSC were examined by qRT-PCR, ELISA, Western blotting and confocal microscopy. Co-immunoprecipitation (Co-IP) assays were performed to evaluate the interaction between p62 and SPP1. The immunomodulatory function of BMSCs on macrophage polarization was identified by transwell co-culture system with macrophage cells THP-1. The macrophage-associated marker expression was analyzed using WB and immunofluorescence, while the secretion of inflammatory cytokines was measured by ELISA. Phenotypic characterization demonstrated that BMSCs possessed canonical MSC morphology, belong to CD73
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.