ArticleNature communications2026
An epifluorescence microscope design for naturalistic behavior and cellular activity in freely moving Caenorhabditis elegans.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Large vision model framework for automated C. elegans analysis: From static morphometry to dynamic neural activity.PLoS computational biology · 2026Article
- A modular multi-color fluorescence microscope for simultaneous tracking of cellular activity and behavior.Nature communications · 2026Article
- An epifluorescence microscope design for naturalistic behavior and cellular activity in freely moving Caenorhabditis elegans.Nature communications · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Understanding the neural basis of behavior requires imaging cellular activity in freely moving animals, which typically demands expensive, restrictive microscopy setups. To overcome these barriers, we developed Wormspy, a cost-effective, open-source epifluorescence microscopy system for high-magnification imaging and tracking of Caenorhabditis elegans. Wormspy enables the simultaneous recording of neuronal activity and behavioral dynamics without needing the animal to be restrained. We demonstrate its utility in imaging body wall muscles, sensory neurons, and subcellular calcium events within interneuron axons. Our platform reproduces known mutant phenotypes and uncovers, to the best of our knowledge, previously inaccessible sensorimotor correlations. We show that Wormspy provides a robust, modular framework that lowers technical barriers to high-resolution neural imaging, enabling flexible experimental designs for dissecting behavior in freely moving organisms.
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Registered trials
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