Evidence map›Paper›PMID 42156637›Full record

ArticleTranslational stroke research2026

Associations of Blood Soluble Fas and IGF-I with Risk of Hemorrhagic Stroke: The Circulatory Risk Communities Study (CIRCS).

Kenichi Ariyada, Tomoko Sankai, Kazumasa Yamagishi, Isao Muraki, Yuji Shimizu, Hironori Imano, Takeshi Tanigawa, Hiroyasu Iso

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational stroke research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kenichi AriyadaDepartment of Public Health Medicine, Institute of Medicine, and Health Services Research and Development Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8577, Ibaraki, Japan.
Tomoko SankaiDepartment of Public Health Medicine, Institute of Medicine, and Health Services Research and Development Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8577, Ibaraki, Japan.
Kazumasa YamagishiDepartment of Public Health Medicine, Institute of Medicine, and Health Services Research and Development Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8577, Ibaraki, Japan. yamagishi.kazumas.ge@u.tsukuba.ac.jp.ORCID http://orcid.org/0000-0003-3301-5519
Isao MurakiDepartment of Public Health Medicine, Institute of Medicine, and Health Services Research and Development Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8577, Ibaraki, Japan.
Yuji ShimizuEpidemiology Section, Division of Public Health, Osaka Institute of Public Health, 1-3-3 Nakamichi, Higashinari Ward, 537-0025, Osaka, Japan.
Hironori ImanoDepartment of Public Health, Kindai University Faculty of Medicine, 377-2 Onohigashi, Osakasayama, 589-8511, Osaka, Japan.
Takeshi TanigawaDepartment of Public Health, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo City, 113-8421, Tokyo, Japan.
Hiroyasu IsoInstitute for Global Health Policy Research, Bureau of Global Health Cooperation, Japan Institute for Health Security, 1-21-1 Toyama, Shinjuku- ku, Tokyo, 162-8655, Japan.

Funding

Japan Society for the Promotion of Science 23590776Japan Society for the Promotion of Science 25H01090
6 · The paper itself

Abstract

backgroundAlthough several studies have examined the associations between apoptosis-related factors or growth factors and cardiovascular diseases, evidence on their prospective association with hemorrhagic stroke remains limited.

methodsWe conducted a nested case-control study within the large cohort of the Circulatory Risk in Communities Study in Japan. A total of 98 cases (60 intracerebral hemorrhage and 38 subarachnoid hemorrhage; 34 men and 64 women, aged 35 to 83 years at baseline) were included, along with 196 controls matched by age, sex, community, and year of sample collection. We measured serum levels of the soluble form of Fas and insulin-like growth factor-I among cases and controls. The odds ratios of total hemorrhagic stroke and its subtypes were calculated using conditional logistic regression analyses.

resultsThe median follow-up period from baseline to onset was 7.0 years. The multivariable odds ratios (95% confidence intervals) of total hemorrhagic stroke associated with a 1-standard deviation increment of soluble Fas (2.3 ng/mL) and insulin-like growth factor-I (40.5 ng/mL) were 0.93 (0.66-1.32) and 0.61 (0.41-0.89), respectively. The inverse association with insulin-like growth factor-I levels was similar for subarachnoid hemorrhage and intracerebral hemorrhage: the respective multivariable odds ratios were 0.53 (0.28-0.98) and 0.62 (0.37-1.04).

conclusionsThe present study identified an inverse association between insulin-like growth factor-I levels and the risk of hemorrhagic stroke.

Indexed as

fas ReceptorHemorrhagic StrokeInsulin-Like Growth Factor IAdultAgedAged, 80 and overBiomarkersCase-Control StudiesFemaleHumansJapanMaleMiddle AgedRisk FactorsBiomarkersFAS protein, humanfas ReceptorIGF1 protein, humanInsulin-Like Growth Factor ICohort studyHemorrhagic strokeIGF-IIntracerebral hemorrhageSoluble FasSubarachnoid hemorrhage

Identifiers

PMID42156637
PMCPMC13186836

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.