Evidence map›Paper›PMID 42156616›Full record

ReviewJournal of natural medicines2026

A comprehensive review on the chemical composition, pharmacological effects and quality evaluation of Gentiana straminea Maxim.

Yuan-Wen Zhuang, Min Wang, Jian-Tao Zhao, Yu-Qing Wang, Run-Qian Yu, Huan Xia, Xiao-Hong Wei, Peng-Cheng Lin, Gui-Yang Xia, Sheng Lin

Abstract readReview
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In one paragraph

Review in Journal of natural medicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuan-Wen Zhuang *College of Pharmaceutical Sciences, Qinghai University for Nationalities, Xining, 810000, China.
Min Wang *College of Pharmaceutical Sciences, Qinghai University for Nationalities, Xining, 810000, China.
Jian-Tao ZhaoCollege of Pharmaceutical Sciences, Qinghai University for Nationalities, Xining, 810000, China.
Yu-Qing WangCollege of Pharmaceutical Sciences, Qinghai University for Nationalities, Xining, 810000, China.
Run-Qian YuCollege of Pharmaceutical Sciences, Qinghai University for Nationalities, Xining, 810000, China.
Huan XiaKey Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China.
Xiao-Hong WeiKey Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China.
Peng-Cheng LinCollege of Pharmaceutical Sciences, Qinghai University for Nationalities, Xining, 810000, China. qhlpc@126.com.
Gui-Yang XiaKey Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China. nyxiaguiyang@163.com.
Sheng LinCollege of Pharmaceutical Sciences, Qinghai University for Nationalities, Xining, 810000, China. lsznn@bucm.edu.cn.

Funding

Science and Technology Plan of Qinghai Province - Key Research and Development and Transformation Plan No. 2022-SF-141
6 · The paper itself

Abstract

Gentiana straminea Maxim. (GSM), a cornerstone medicinal plant in Tibetan ethnopharmacology, has been utilized for over two millennia. This species exhibits a wide distribution across China, predominantly in the northwest. Its roots and flowers characterized by bitter, pungent taste and neutral properties are used medicinally. Traditional applications include treating rheumatoid arthritis, icteric hepatitis, leprosy, and "toxic heat" syndromes. Recent research has identified critical bioactive constituents: secoiridoids (gentiopicroside, swertiamarin, sweroside), loganic acid, flavonoids (vitexin, isovitexin), volatile compounds, and saccharides. GSM demonstrates significant pharmacological activities, including anti-inflammatory, analgesic, antioxidant, hepatoprotective, cardioprotective, anti-hypoxic, anti-bacterial, and insecticidal effects. By systematically reviewing domestic and international literature from the past two decades, this study summarizes the morphological characteristics, resource distribution, breeding practices, cultivation methods, chemical composition, and pharmacological actions of GSM. The aim is to provide a scientific basis for its cultivation, identification, rational clinical application, and to promote its development and utilization.

Indexed as

GentianaPlant ExtractsAnimalsHumansPlants, MedicinalPlant ExtractsChemical compositionCultivationGentiana straminea Maxim.Pharmacological actionQuality control

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.