ArticleJournal of materials science. Materials in medicine2026
Surface modification of urinary catheters with antibiofilm nanocoating: curcumin modified silver nanoparticles against Proteus mirabilis.
Article in Journal of materials science. Materials in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteus mirabilis is a Gram-negative, uropathogenic bacterium with high virulence due to its crystalline biofilm-forming ability, urease production, and antibiotic resistance. Nanotechnology has emerged as a promising field to address such challenges, offering innovative solutions to combat bacterial virulence and antibiotic resistance. This study aimed to develop a urinary catheter surface coated with curcumin-modified silver nanoparticles (Curcumin-AgNPs) to reduce crystalline biofilm formation by P.mirabilis. The coating was assessed using Fourier-transform infrared spectroscopy (FTIR), atomic force microscopy(AFM), scanning electron microscopy-energy-dispersive X-ray analysis(SEM-EDX), and contact angle assays. The antimicrobial efficacy was examined by direct contact assay, serial plate transfer test (SPTT), and time kill assay. Coated catheters were experimented with using an in vitro bladder model over 2, 7, and 14 days, and at the point of catheter blockage. Antibiofilm efficacy was examined using tetrazolium salt 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT), crystal violet(CV) assays, SEM-EDX, and atomic absorption spectroscopy(AAS) analysis. P-values < 0.05 were considered statistically significant. FTIR, AFM, SEM, and EDX analyses confirmed the successful coating of the Foley catheter with curcumin-AgNPs. A contact angle measurement of 120.11° demonstrated the hydrophobic nature of the coated catheter. The direct contact assay revealed inhibition zones for coated catheters (11.85 ± 1.86 mm). The coating demonstrated strong antibiofilm activity, with 70 - 80% biomass reduction and 60-80% metabolic inhibition even at the point of catheter blockage. AAS, SEM-EDX analysis showed reduced Ca²⁺ and Mg²⁺ deposition in coated catheters. The findings indicate that curcumin-AgNPs coatings markedly improve the antibacterial and antibiofilm efficacy of urinary catheters, successfully inhibiting crystalline biofilm formation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.