Evidence map›Paper›PMID 42156572›Full record

SynthesisSurgical endoscopy2026

Role of topical self-assembling peptide in preventing delayed bleeding following advanced endoscopic resection: a systematic review and meta-analysis.

Dimo Dimitrov, Harishankar Gopakumar, Daryl Ramai, Kobina Essilfie-Quaye, Lynn Warner, Sulaiman Almushir, Jason Dubroff, Faisal Aljohani, Abdulrahman Qatomah, Hiroyuki Aihara

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dimo DimitrovDivision of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0009-0000-6221-4993
Harishankar GopakumarDivision of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, MA, USA.
Daryl RamaiDivision of Gastroenterology, Hepatology and Nutrition, University of Utah School of Medicine, Salt Lake City, UT, USA.
Kobina Essilfie-QuayeDepartment of Internal Medicine, HCA Florida North Florida Hospital, Gainesville, FL, USA.
Lynn WarnerSystematic Review Services Specialization, Academic & Research Services Librarian, University of Cincinnati, Cincinnati, OH, USA.
Sulaiman AlmushirDivision of Gastroenterology and Hepatology, McGill University Health Center, Montreal, QC, Canada.
Jason DubroffDivision of Gastroenterology, Hepatology and Nutrition, University of Utah School of Medicine, Salt Lake City, UT, USA.
Faisal AljohaniDepartment of Medicine, Tabouk University, Tabouk, Saudi Arabia.
Abdulrahman QatomahDivision of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, MA, USA.
Hiroyuki AiharaDivision of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, MA, USA. Haihara@bwh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDelayed bleeding following endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR) remains a recognized adverse event. Despite observational studies suggesting lower delayed bleeding rates with the use of self-assembling peptide (SAP), randomized data have yielded inconsistent results, precluding routine prophylactic application. We aimed to evaluate the effectiveness of SAP in preventing delayed bleeding after ESD and EMR.

methodsWe systematically searched PubMed, Embase, and the Cochrane Library through October 2025 for prospective or retrospective cohorts reporting delayed bleeding following ESD or EMR in direct association with adjunctive SAP application, with or without a comparator group. Random-effects meta-analyses estimated pooled delayed bleeding rates and, where applicable, risk ratios (RR), with prespecified subgroup analyses by resection technique.

resultsEleven studies comprising 928 patients were included. Comparative analyses (five studies), SAP in conjunction with standard therapy was not associated with a reduction in delayed bleeding compared with standard care (RR 1.34, 95% CI 0.83-2.18; I

conclusionProphylactic SAP after ESD or EMR yielded delayed bleeding rates comparable to baseline, indicating no added benefit over standard practice. In anticoagulated patients, outcomes similarly matched historical benchmarks, with no evident protective effect. Further studies are required to define the patients most likely to benefit from SAP.

Indexed as

Endoscopic Mucosal ResectionPeptidesPostoperative HemorrhageAdministration, TopicalHumansPeptidesDelayed bleedingEndoscopic mucosal resectionEndoscopic submucosal dissectionHemostatic agentsSelf-assembling peptide

Identifiers

PMID42156572

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.