ArticleScientific reports2026
Integrated anatomical and functional connectivity mapping in episodic migraine: a spectral graph theory approach.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Migraine disproportionately affects women, yet how migraine physiology reshapes large-scale brain communication remains unclear. We combined diffusion-weighted imaging (DWI) and resting-state fMRI in female participants (14 patients with episodic migraine without aura; 15 matched healthy controls) to test how direct and indirect anatomical communication paths in the brain can predict brain function. We used a spectral mapping framework that isolates the contribution of communication paths of a specific length and evaluated how well brain structure predicts brain function within individuals. Analyses of individual path lengths revealed a non-monotonic dissociation: no difference at one-step (direct) paths, but higher mapping accuracy in patients at intermediate indirect scales (four and five steps). At longer scales, contributions attenuated in both groups. Spatial correspondence analyses localized patient-specific effects to default mode network subsystems across multiple atlases. These findings indicate that migraine-related dysfunction reflects altered mesoscale structure-function integration along indirect anatomical routes, and they provide a general approach to dissect structure-function coupling by communication scale in disease.
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