Evidence map›Paper›PMID 42156501›Full record

ArticleScientific reports2026

Systemic sclerosis in children and older juvenile-onset patients: real-life map by the Egyptian college of Rheumatology.

Hania S Zayed, Tamer A Gheita, Nevin Hammam, Manal Hassanien, Gehad Gamal Maghraby, Nermeen Samy, Nermeen N Aziz, Abdelhfeez Moshrif, Yousra H Abdel-Fattah, Amany R El-Najjar and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Hania S ZayedRheumatology Department, Faculty of Medicine, Cairo University, Kasr Alainy, Cairo, 11956, Egypt. hania.zayed@kasralainy.edu.eg.
Tamer A GheitaRheumatology Department, Faculty of Medicine, Cairo University, Kasr Alainy, Cairo, 11956, Egypt.
Nevin HammamRheumatology Department, Faculty of Medicine, Assiut University, Assiut University street, Assiut, 71515, Egypt.
Manal HassanienRheumatology Department, Faculty of Medicine, Assiut University, Assiut University street, Assiut, 71515, Egypt.
Gehad Gamal MaghrabyInternal Medicine Department, Rheumatology and Clinical Immunology Unit, Faculty of Medicine, Cairo University, Kasr Alainy, Cairo, 11956, Egypt.
Nermeen SamyInternal Medicine Department, Rheumatology Unit, Faculty of Medicine, Ain Shams University, Abbasiya, Cairo, 11566, Egypt.
Nermeen N AzizInternal Medicine Department, Rheumatology Unit, Faculty of Medicine, Ain Shams University, Abbasiya, Cairo, 11566, Egypt.
Abdelhfeez MoshrifRheumatology Department, Faculty of Medicine, Al- Azhar University, 1 Al-Azhar University Square, King Faisal, Assiut, 71524, Egypt.
Yousra H Abdel-FattahRheumatology Department, Faculty of Medicine, Alexandria University, Elazarita, Medan Elkhartoum, 21111, Alexandria, Egypt.
Amany R El-NajjarRheumatology Department, Faculty of Medicine, Zagazig University, Al Sharkia Governorate, Zagazig, 44519, Egypt.
Enas A AbdelaleemRheumatology Department, Faculty of Medicine, Beni- Suef University, Mokbel, Beni-Suef, 62511, Egypt.
Fatma A MohamedRheumatology Department, Faculty of Medicine, Minia University, Egypt-Aswan Agricultural Road, Minia, 61519, Egypt.
Rania M GamalRheumatology Department, Faculty of Medicine, Assiut University, Assiut University street, Assiut, 71515, Egypt.
Amany S El-BahnasawyRheumatology Department, Faculty of Medicine, Mansoura University, Elgomhoreya street, Mansoura, 35516, Egypt.
Khaled A A AbdelgalilRheumatology Department, Faculty of Medicine, Aswan University, Aswan, 81528, Egypt.
Dina F El-EssawiHealth Radiation Research Department, Internal Medicine Unit, Rheumatology Clinic, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, 3 Ahmed Elzmor street, Nasr City, Cairo, 11762, Egypt.
Reem El-MallahRheumatology Department, Faculty of Medicine, Ain Shams University, Abbasiya, Cairo, 11566, Egypt.
Thanaa F MansourInternal Medicine Department, Rheumatology Unit, Faculty of Medicine, Tanta University, Elbahr Street, Tanta, 31111, Al Gharbiya Governorate, Egypt.
Eman F MohamedInternal Medicine Department, Rheumatology Unit, Faculty of Medicine for Girls, Al-Azhar University, 38 Youssef Abbas street, Nasr City, Cairo, 11754, Egypt.
Noha A AzabRheumatology Department, Faculty of Medicine, Cairo University, Kasr Alainy, Cairo, 11956, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this work was to present the demographic and clinical features of children with juvenile systemic sclerosis (JSSc) compared to their older juvenile-onset (Jo-SSc) counterparts. The study included 12 JSSc children (< 16 years) and 54 Jo-SSc patients > 16 years (including adolescents and adults) recruited from 15 tertiary care centers across Egypt. Patients were classified as diffuse (dcSSc), limited cutaneous SSc (lcSSc) and overlap. The mean age at disease onset was 14 ± 2.5 years. Patients were 62 females and 4 males (F: M 15.5:1); 37 lcSSc, 26 dcSSc and 3 overlap. Disease features were generally comparable across five regions of Egypt. Pitting scars and hand puffiness were significantly more frequent in JSSc (58.3% and 41.7%) compared to Jo-SSc (16.7% and 14.8%) (p = 0.006 and p = 0.049, respectively) while pulmonary hypertension was more common in Jo-SSc (40.7% vs. 8.3%, p = 0.045). All males, currently with Jo-SSc, had gastrointestinal involvement versus n = 24 (38.7%) in females, p < 0.0001. To conclude, SSc in children and in those who grow into adulthood remains a rare disease. Pitting scars and hand puffiness were more frequent in children with JSSc while pulmonary hypertension became prominent as they grew. Children characteristics are special for each nation yet with similarities in some features.

Indexed as

Scleroderma, SystemicAdolescentAge of OnsetChildEgyptFemaleHumansHypertension, PulmonaryMaleRheumatologyChildrenEgyptian college of RheumatologyGenderJuvenile-onsetOverlapPediatric systemic sclerosis

Identifiers

PMID42156501
PMCPMC13187294

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.