ArticleScientific reports2026
Oncolytic vaccinia virus JX-594 shows subtype-specific activity and candidate biomarkers in gastric cancer cell lines.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Oncolytic vaccinia virus JX-594 (pexastimogene devacirepvec) selectively replicates in tumour cells and stimulates antitumour immunity; however, its therapeutic potential in gastric cancer (GC) has not been systematically evaluated. In this study, we investigated the antitumour activity of JX-594 across a panel of 49 molecularly characterized GC cell lines and a xenograft mouse model and explored molecular features associated with viral sensitivity. JX-594 induced cytopathic effects (median effective dose, ED
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