ArticleScientific reports2026
Neurocognitive effects of postbiotics from Lactobacillus and Bifidobacterium strains in a mouse model of chronic variable stress.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut-brain axis serves as a vital communication pathway through which gut microbiota modulates central nervous system function. Chronic stress disrupts this balance, leading to gut dysbiosis, neuroinflammation, and cognitive decline. While probiotics have been widely investigated, the therapeutic properties of their non-viable metabolites, postbiotics, are less understood. This study examined the neurocognitive effects of postbiotics derived from Lactobacillus rhamnosus and Bifidobacterium longum in a mouse model of chronic variable stress (CVS). Male BALB/c mice underwent a four-week CVS protocol, followed by eight weeks of oral postbiotic administration (10⁹ CFU/mL bacterial supernatant) from individual or mixed strains. Cognitive performance was evaluated using the Morris Water Maze (MWM), Novel Object Recognition (NOR), and Shuttle Box tests, while hippocampal expression of AKT and Arc, genes linked to learning and memory, was analyzed by qRT-PCR. CVS markedly impaired performance across all cognitive tests. Postbiotic supplementation significantly reversed these deficits, with Bifidobacterium longum postbiotics exerting the most robust effects. Treated mice showed reduced escape latency and shorter platform distance in the MWM, improved discrimination in the NOR test, and increased latency to the dark compartment in the Shuttle Box, indicating enhanced spatial, recognition, and inhibitory memory. These behavioral improvements correlated with upregulated hippocampal AKT and Arc expression, suggesting strengthened synaptic signaling. Overall, postbiotic treatment, particularly from Bifidobacterium longum, effectively mitigated stress-induced cognitive dysfunction, highlighting postbiotics as promising therapeutic agents for stress-related and neurodegenerative cognitive impairments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.