Evidence map›Paper›PMID 42156413›Full record

ArticleNature communications2026

Integrated genomic analyses identify oncogenic pathway interplay in hepatocarcinogenesis defining specific molecular subtypes.

Long Pan, Théo Z Hirsch, Jing Fang, Agnieszka Seretny, Sandrine Imbeaud, Shuoshuo Jin, Olatunji Oluwole Gege, Sandra Rebouissou, Sabrina Sidali, Naïma Ammiche and 13 more

Abstract read
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In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Long PanTeam « Functional Genomics of Solid Tumors », Cordeliers Research Center, Sorbonne Université, Inserm, Université Paris Cité, équipe Labellisée Ligue Contre le Cancer, Paris, France.ORCID http://orcid.org/0000-0003-1550-8280
Théo Z HirschTeam « Functional Genomics of Solid Tumors », Cordeliers Research Center, Sorbonne Université, Inserm, Université Paris Cité, équipe Labellisée Ligue Contre le Cancer, Paris, France.ORCID http://orcid.org/0000-0003-4428-2997
Jing FangTeam « Genomic Instability, Metabolism, Immunity and Liver Tumorigenesis », Cordeliers Research Center, Sorbonne Université, Inserm, Université Paris Cité, équipe Labellisée Ligue Contre le Cancer, Paris, France.
Agnieszka SeretnyHelmholtz-University Group Cell Plasticity and Epigenetic Remodeling, German Cancer Research Center (DKFZ) and Institute of Pathology University Hospital Heidelberg, Heidelberg, Germany.
Sandrine ImbeaudTeam « Functional Genomics of Solid Tumors », Cordeliers Research Center, Sorbonne Université, Inserm, Université Paris Cité, équipe Labellisée Ligue Contre le Cancer, Paris, France.ORCID http://orcid.org/0000-0001-8439-6732
Shuoshuo JinTeam « Functional Genomics of Solid Tumors », Cordeliers Research Center, Sorbonne Université, Inserm, Université Paris Cité, équipe Labellisée Ligue Contre le Cancer, Paris, France.
Olatunji Oluwole GegeHelmholtz-University Group Cell Plasticity and Epigenetic Remodeling, German Cancer Research Center (DKFZ) and Institute of Pathology University Hospital Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0009-0003-0800-0507
Sandra RebouissouTeam « Functional Genomics of Solid Tumors », Cordeliers Research Center, Sorbonne Université, Inserm, Université Paris Cité, équipe Labellisée Ligue Contre le Cancer, Paris, France.
Sabrina SidaliTeam « Functional Genomics of Solid Tumors », Cordeliers Research Center, Sorbonne Université, Inserm, Université Paris Cité, équipe Labellisée Ligue Contre le Cancer, Paris, France.
Naïma AmmicheTeam « Functional Genomics of Solid Tumors », Cordeliers Research Center, Sorbonne Université, Inserm, Université Paris Cité, équipe Labellisée Ligue Contre le Cancer, Paris, France.
Julien CalderaroDepartment of Pathology, Assistance Publique Hôpitaux de Paris, Groupe Hospitalier Henri Mondor, Créteil, France.
Giuliana AmaddeoDepartment of Hepatology, Assistance Publique-Hôpitaux de Paris, Henri Mondor-Albert Chenevier University Hospital, Créteil, France.
Jean-Frédéric BlancOncology Digestive Unit, INSERM U1312, University Hospital of Bordeaux, Bordeaux, France.
Brigitte Le BailDepartment of Pathology, Hôpital Pellegrin, Bordeaux University Hospital, Bordeaux, France.
Marianne ZiolTeam « Functional Genomics of Solid Tumors », Cordeliers Research Center, Sorbonne Université, Inserm, Université Paris Cité, équipe Labellisée Ligue Contre le Cancer, Paris, France.ORCID http://orcid.org/0000-0001-5117-4842
Séverine Celton-MorizurTeam « Genomic Instability, Metabolism, Immunity and Liver Tumorigenesis », Cordeliers Research Center, Sorbonne Université, Inserm, Université Paris Cité, équipe Labellisée Ligue Contre le Cancer, Paris, France.
Valérie ParadisDepartment of pathology, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Clichy, France.ORCID http://orcid.org/0000-0003-3142-3762
Josep M LlovetMount Sinai Liver Cancer Program, Divisions of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-0547-2667
Darjus Felix TschaharganehHelmholtz-University Group Cell Plasticity and Epigenetic Remodeling, German Cancer Research Center (DKFZ) and Institute of Pathology University Hospital Heidelberg, Heidelberg, Germany.
Jean-Charles NaultTeam « Functional Genomics of Solid Tumors », Cordeliers Research Center, Sorbonne Université, Inserm, Université Paris Cité, équipe Labellisée Ligue Contre le Cancer, Paris, France.
Chantal DesdouetsTeam « Genomic Instability, Metabolism, Immunity and Liver Tumorigenesis », Cordeliers Research Center, Sorbonne Université, Inserm, Université Paris Cité, équipe Labellisée Ligue Contre le Cancer, Paris, France.ORCID http://orcid.org/0000-0002-1955-8915
Stefano CarusoTeam « Functional Genomics of Solid Tumors », Cordeliers Research Center, Sorbonne Université, Inserm, Université Paris Cité, équipe Labellisée Ligue Contre le Cancer, Paris, France.
Jessica Zucman-RossiTeam « Functional Genomics of Solid Tumors », Cordeliers Research Center, Sorbonne Université, Inserm, Université Paris Cité, équipe Labellisée Ligue Contre le Cancer, Paris, France. jessica.zucman-rossi@inserm.fr.ORCID http://orcid.org/0000-0002-5687-0334

Funding

The Role of KLF6 in Hepatic FibrosisR01DK056621 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI FRIEDMAN, SCOTT L. · 2000 to 2019
$6.2M
Hepatic stellate cells in NASH fibrosis and HCCR01DK128289 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCOTT L. FRIEDMAN · 2021 to 2026
$2.6M
Determinants of immunotherapy response in NASH-Hepatocellular carcinomaR01CA273932 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JOSEP M LLOVET · 2023 to 2026
$2.0M
NCI NIH HHS R01 CA273932NIDDK NIH HHS R01 DK056621NIDDK NIH HHS R01 DK128289
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a genomically diverse disease, and molecular classification is essential for understanding its biology and improving patient care. Here, integrative analyses of 529 HCC samples across genomic, transcriptomic, epigenomic, and proteomic layers identify nine robust molecular subtypes, validated in 807 external cases. Three common subtypes are defined by alterations in CTNNB1

Indexed as

CarcinogenesisCarcinoma, HepatocellularLiver Neoplasmsbeta CateninGene Expression Regulation, NeoplasticGenomicsHumansMutationProteomicsTumor Suppressor Protein p53beta CateninTumor Suppressor Protein p53

Identifiers

PMID42156413
PMCPMC13381854

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.