ArticleNature communications2026
Structural basis for dual mechanism of Cas2/3 nuclease inhibition by anti-CRISPR protein AcrIF19.
Yuanshuo Sa, Chunlei Liu, Lingguang Yang, Ling Yue, Limin Zhu, Ying Guo, Ruimei Wang, Yafei Wang, Yue Feng, Yong Wang and 3 more
Abstract read
In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
13 authors.
Yuanshuo Sa *National Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University, Tai'an, China.
Chunlei Liu *National Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University, Tai'an, China.
Ling Yue *National Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University, Tai'an, China.
Limin ZhuNational Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University, Tai'an, China.
Ying GuoNational Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University, Tai'an, China.
Ruimei WangNational Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University, Tai'an, China.
Yafei WangNational Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University, Tai'an, China.
Yi ZhangState Key Laboratory of Green Biomanufacturing, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China. zhangyishirly@hotmail.com.
Wenhe WangDepartment of Biological Science and Engineering, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, China. wenhewang@hotmail.com.ORCID http://orcid.org/0000-0002-1040-520X Funding
National Natural Science Foundation of China (National Science Foundation of China) 32301058National Natural Science Foundation of China (National Science Foundation of China) 32371329, 32301055，32400565，32560225Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation) ZR202211190090Taishan Scholar Project of Shandong Province tsqn202306146
6 · The paper itselfAbstract
CRISPR-Cas systems are prokaryotic immune mechanisms often targeted by phage-encoded anti-CRISPR (Acr) proteins. This study characterizes AcrIF19, a potent inhibitor of the type I-F system in Pectobacterium atrosepticum. The cryo-EM structure of the apo Cas2/3 and Cas2/3-AcrIF19 complex reveals a dual inhibitory mechanism. AcrIF19 employs a negatively charged β
Indexed as
Bacterial ProteinsCRISPR-Associated ProteinsCRISPR-Cas SystemsViral ProteinsAllosteric RegulationCryoelectron MicroscopyDNA CleavageDNA, Single-StrandedModels, MolecularBacterial ProteinsCRISPR-Associated ProteinsDNA, Single-StrandedViral Proteins
Identifiers
PMID42156407
PMCPMC13381967
What OpenQuestion holds
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