Evidence map›Paper›PMID 42156393›Full record

ArticleNature communications2026

Multiomics analysis of the molecular and single-cell responses of rice after deep-space flight on Chang'e-5.

Kai Sun, Jiameng Zhang, Haonan Li, Wenjing Song, Qunjie Zhang, Liqiu Ma, Jiafeng Wang, Wuming Xiao, Guili Yang, Ming Huang and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Kai SunGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, South China Agricultural University, Guangzhou, PR China.
Jiameng ZhangNational Engineering Research Center of Plant Space Breeding, South China Agricultural University, Guangzhou, PR China.
Haonan LiNational Engineering Research Center of Plant Space Breeding, South China Agricultural University, Guangzhou, PR China.
Wenjing SongNational Engineering Research Center of Plant Space Breeding, South China Agricultural University, Guangzhou, PR China.
Qunjie ZhangCollege of Agriculture, South China Agricultural University, Guangzhou, PR China.
Liqiu MaDepartment of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan.
Jiafeng WangGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, South China Agricultural University, Guangzhou, PR China.
Wuming XiaoGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, South China Agricultural University, Guangzhou, PR China.
Guili YangNational Engineering Research Center of Plant Space Breeding, South China Agricultural University, Guangzhou, PR China.
Ming HuangNational Engineering Research Center of Plant Space Breeding, South China Agricultural University, Guangzhou, PR China.
Cuihong HuangNational Engineering Research Center of Plant Space Breeding, South China Agricultural University, Guangzhou, PR China.
Danhua ZhouNational Engineering Research Center of Plant Space Breeding, South China Agricultural University, Guangzhou, PR China.
Renjia ShenNational Engineering Research Center of Plant Space Breeding, South China Agricultural University, Guangzhou, PR China.
Chun ChenNational Engineering Research Center of Plant Space Breeding, South China Agricultural University, Guangzhou, PR China.
Meng ZhangCollege of Environmental Sciences and Engineering, Dalian Maritime University, Dalian, PR China.
Chenyang ZhaoCollege of Environmental Sciences and Engineering, Dalian Maritime University, Dalian, PR China.
Zeyan HuangCollege of Agriculture, South China Agricultural University, Guangzhou, PR China.
Ping WangInstitute of Biotechnology and Nuclear Technology, Sichuan Academy of Agricultural Sciences, Chengdu, PR China.
Jian ZhangInstitute of Biotechnology and Nuclear Technology, Sichuan Academy of Agricultural Sciences, Chengdu, PR China.
Jian ZengSchool of Biology and Agriculture, Shaoguan University, Shaoguan, PR China.
Yongzhu LiuGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, South China Agricultural University, Guangzhou, PR China.
Hui WangNational Engineering Research Center of Plant Space Breeding, South China Agricultural University, Guangzhou, PR China.
Zhiqiang ChenNational Engineering Research Center of Plant Space Breeding, South China Agricultural University, Guangzhou, PR China. chenlin@scau.edu.cn.
Tao GuoGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, South China Agricultural University, Guangzhou, PR China. guoguot@scau.edu.cn.ORCID http://orcid.org/0000-0003-4042-7810

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deep-space conditions exert severe stress on plant genome stability, gene expression, epigenetic modification, and cell differentiation. In this study, multiomics analysis is used to observe changes in rice at the molecular and cellular levels after deep-space flight, including an increase in the frequency and types of mutations. While overall DNA methylation levels do not significantly change, CHG methylation levels present an increase that is correlated with DNA methylation responses. RNA presents significantly elevated m6A modification levels, which positively regulate gene expression. The proportion of mesophyll cells decreases, and 188 genes are identified as affecting the differentiation of mesophyll cells. Integrated multiomics analysis supports a hypothesis that the NAC family transcription factor suppressor of variation transmission 1 (SVT1) negatively regulates MAPK pathway genes, potentially influencing differentiation of cells harbouring mutations. Overall, this study comprehensively describes the molecular map of rice after deep-space flight and proposes a putative mechanism through which SVT1 may adapt to deep-space flight by inhibiting the differentiation of cells harbouring mutations.

Indexed as

Adaptation, PhysiologicalOryzaSpace FlightDNA MethylationGene Expression Regulation, PlantMAP Kinase Signaling SystemMultiomicsMutationPlant ProteinsRNA MethylationSingle-Cell AnalysisTranscription FactorsPlant ProteinsTranscription Factors

Identifiers

PMID42156393
PMCPMC13381868

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.