Evidence map›Paper›PMID 42156327›Full record

ArticleJournal of the American Chemical Society2026

Light-Activated RPE65 Inhibitors Enable On-Demand Visual Cycle Control.

Marco Bassetto, Bowen Li, Xiuyuan Chen, Jianye Zhang, Yulun Hu, Jordan Zaluski, Lauren M Brumit, Preston M Willis, Felix Grun, Krzysztof Palczewski and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marco BassettoDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, California 92697, United States.ORCID 0000-0003-0048-0203
Bowen LiDepartment of Chemistry, College of Arts and Sciences, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Xiuyuan ChenDepartment of Chemistry, College of Arts and Sciences, Case Western Reserve University, Cleveland, Ohio 44106, United States.ORCID 0009-0002-1363-1672
Jianye ZhangGavin Herbert Eye Institute-Robert M. Brunson Center for Translational Vision Research, Department of Ophthalmology and Visual Sciences, University of California, Irvine, Irvine, California 92697, United States.
Yulun HuDepartment of Chemistry, College of Arts and Sciences, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Jordan ZaluskiDepartment of Chemistry, College of Arts and Sciences, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Lauren M BrumitDepartment of Chemistry, College of Arts and Sciences, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Preston M WillisDepartment of Chemistry, College of Arts and Sciences, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Felix GrunDepartment of Chemistry, University of California, Irvine, Irvine, California 92697, United States.
Krzysztof PalczewskiDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, California 92697, United States.ORCID 0000-0002-0788-545X
Philip D KiserDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, California 92697, United States.ORCID 0000-0003-1184-9539
Gregory P TochtropDepartment of Chemistry, College of Arts and Sciences, Case Western Reserve University, Cleveland, Ohio 44106, United States.ORCID 0000-0003-2447-254X

Funding

STRUCTURAL STUDIES OF ARRESTINSR01EY009339 · NEI · UNIVERSITY OF WASHINGTON · PI KISER, PHILIP DAVID, PALCZEWSKI, KRZYSZTOF · 1992 to 2025
$16.0M
BLRD VA I01 BX004939BLRD VA IK6 BX006800NEI NIH HHS R01 EY009339
6 · The paper itself

Abstract

Light initiates visual perception, but it also exacerbates a subset of blinding diseases in which visual (retinoid) cycle metabolic intermediates contribute to pathophysiology. Small molecule visual cycle modulators (VCMs) have demonstrated efficacy in preclinical models, but have been limited clinically by chronic, indiscriminate visual cycle suppression leading to side effects including night blindness in human subjects. Here, we demonstrate VCMs that are activated via a

Indexed as

Azo Compoundscis-trans-IsomerasesEnzyme InhibitorsLightAnimalsHumansRetinaRetinoid IsomerohydrolaseazobenzeneAzo Compoundscis-trans-IsomerasesEnzyme InhibitorsRetinoid Isomerohydrolase

Identifiers

PMID42156327
PMCPMC13244443

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.