Evidence map›Paper›PMID 42156171›Full record

ArticleGut2026

Endosomal signalling of protease-activated receptor-2 amplifies histamine-induced pain of irritable bowel syndrome.

Nestor N Jimenez-Vargas, Badr Sokrat, Daniella A Gilmor, Maria F P Fialho, Mabel Guzman-Rodriguez, Rita Nakhle, Yun Shi, Steve Davidson, Brian L Schmidt, David E Reed and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Nestor N Jimenez-VargasMolecular Pathobiology, New York University, New York, New York, USA.ORCID http://orcid.org/0000-0001-6595-1884
Badr SokratMolecular Pathobiology, New York University, New York, New York, USA.ORCID http://orcid.org/0000-0002-5770-1858
Daniella A GilmorGastrointestinal Diseases Research Unit, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada.
Maria F P FialhoMolecular Pathobiology, New York University, New York, New York, USA.
Mabel Guzman-RodriguezGastrointestinal Diseases Research Unit, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada.
Rita NakhleGastrointestinal Diseases Research Unit, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada.
Yun ShiGastrointestinal Diseases Research Unit, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada.
Steve DavidsonMolecular Pathobiology, New York University, New York, New York, USA.
Brian L SchmidtMolecular Pathobiology, New York University, New York, New York, USA.
David E ReedGastrointestinal Diseases Research Unit, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada.ORCID http://orcid.org/0000-0003-1802-4863
Alan E LomaxGastrointestinal Diseases Research Unit, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada.
Stephen J Vanner *Gastrointestinal Diseases Research Unit, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada.ORCID http://orcid.org/0000-0002-4006-9948
Nigel W Bunnett *Molecular Pathobiology, New York University, New York, New York, USA nwb2@nyu.edu.ORCID http://orcid.org/0000-0003-3367-0644

Funding

Endosomal mechanisms signaling oral cancer painRM1DE033491 · NIDCR · NEW YORK UNIVERSITY · PI NIGEL W BUNNETT, Rajesh Khanna · 2023 to 2026
$6.4M
Targeting Endosomal Receptors for Treatment of Chronic PainR01DE029951 · NIDCR · NEW YORK UNIVERSITY · PI BUNNETT, NIGEL W, SCHMIDT, BRIAN L · 2020 to 2024
$4.7M
Endosomal Platforms for Signaling PainR01NS102722 · NINDS · NEW YORK UNIVERSITY · PI NIGEL W BUNNETT, Brian L Schmidt · 2017 to 2026
$3.4M
Trafficking-Dependent Signaling of Pain by Protease-Activated ReceptorsR01DK118971 · NIDDK · NEW YORK UNIVERSITY · PI BUNNETT, NIGEL W, SCHMIDT, BRIAN L · 2018 to 2021
$3.2M
NIDCR NIH HHS R01 DE029951NIDCR NIH HHS RM1 DE033491NIDDK NIH HHS R01 DK118971NINDS NIH HHS R01 NS102722
6 · The paper itself

Abstract

backgroundProteases and histamine, co-secreted by mast cells and bacteria, sensitise colonic nociceptors and contribute to irritable bowel syndrome (IBS) pain.

objectiveTo determine whether irreversible proteolytic cleavage of protease-activated receptor-2 (PAR

designWe investigated PAR

resultsPAR

conclusionsBy amplifying and maintaining the otherwise transient actions of H

Indexed as

ABDOMINAL PAINIRRITABLE BOWEL SYNDROMESIGNAL TRANSDUCTION

Identifiers

PMID42156171
PMCPMC13381096

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.