Evidence map›Paper›PMID 42156141›Full record

ArticleBMJ open2026

Objective data-driven personalised approach to diagnosis of chronic tinnitus: the Tinnitus Detection (TIDE) project - protocol for the identification and validation of a biomarker for tinnitus.

Sven Vanneste, Anusha Yasoda-Mohan, Feifan Chen, Elva Arulchelvan, Nathan Shields, Christoph Braun, Julia Campbell, Dirk De Ridder, Milena Engelke, Stefan Fink and 18 more

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06520865 (Identification and Validation of a Biomarker for Tinnitus), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06520865 completednot on this map

Identification and Validation of a Biomarker for Tinnitus: an Objective Data-driven Personalized Approach to Diagnosis of Chronic Tinnitus - The Tinnitus Detection (TIDE) Project

TypeobservationalSponsorUniversity of RegensburgRan2024 to 2025Enrolled560ConditionsTinnitusArmsAcoustic paradigms
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Sven VannesteSchool of Psychology, Trinity College Dublin, Dublin, Ireland sven.vanneste@tcd.ie.ORCID http://orcid.org/0000-0003-1513-5752
Anusha Yasoda-MohanTrinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Feifan ChenTrinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Elva ArulchelvanTrinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Nathan ShieldsTrinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Christoph BraunMEG-Center, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Julia CampbellDepartment of Speech, Language, and Hearing Sciences, Central Sensory Processes Lab, The University of Texas at Austin, Austin, Texas, USA.
Dirk De RidderSection of Neurosurgery, Department of Surgical Sciences, University of Otago, Dunedin, New Zealand.
Milena EngelkeDepartment of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
Stefan FinkTübingen Hearing Research Center, Department of Otolaryngology, Head and Neck Surgery, University of Tübingen, Tübingen, Germany.
Fatima T HusainDepartment of Speech and Hearing Science and The Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Namitha JainDepartment of Speech and Hearing Science and The Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.ORCID http://orcid.org/0009-0008-6242-7399
Tobias KleinjungDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland.
Gibbeum KimDepartment of Speech and Hearing Science and The Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Marlies KnipperTübingen Hearing Research Center, Department of Otolaryngology, Head and Neck Surgery, University of Tübingen, Tübingen, Germany.
Berthold LangguthDepartment of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
Hongyu LuTübingen Hearing Research Center, Department of Otolaryngology, Head and Neck Surgery, University of Tübingen, Tübingen, Germany.
Patrick NeffDepartment of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
Lauren RalstonDepartment of Speech, Language, and Hearing Sciences, Central Sensory Processes Lab, The University of Texas at Austin, Austin, Texas, USA.
Elinor RieggerTübingen Hearing Research Center, Department of Otolaryngology, Head and Neck Surgery, University of Tübingen, Tübingen, Germany.
Lukas RüttigerTübingen Hearing Research Center, Department of Otolaryngology, Head and Neck Surgery, University of Tübingen, Tübingen, Germany.
Winfried SchleeDepartment of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
Beat TödtliInstitute of Information and Process Management, Eastern Switzerland University of Applied Sciences, St Gallen, Switzerland.
Payam S ShabestariDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, Zürich, Switzerland.
Shagun AjmeraDepartment of Speech and Hearing Science and The Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Susanne StaudingerDepartment of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.
Stephan WolpertTübingen Hearing Research Center, Department of Otolaryngology, Head and Neck Surgery, University of Tübingen, Tübingen, Germany.
Christopher R CederrothTübingen Hearing Research Center, Department of Otolaryngology, Head and Neck Surgery, University of Tübingen, Tübingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTinnitus is the perception of sound without an external source, often considered a phantom percept similar to phantom limb sensations, resulting from maladaptive plasticity in the brain. The condition lacks an established biomarker for diagnosis but recent studies have linked it to neural changes. The Tinnitus Detection consortium aims to identify and validate potential biomarkers for tinnitus presence and intensity. METHODS/

designThis multicentre prospective case-control study will recruit 560 adults (280 chronic tinnitus; 280 controls). Participants will complete standardised audiological and questionnaire assessments and then undergo 64-channel electroencephalography (and magnetoencephalography at one site) to record event-related potentials during (1) a cortical gap prepulse inhibition of the acoustic startle (GPIAS) paradigm assessing gap-related inhibition of the N1 response and (2) an omission auditory oddball paradigm quantifying mismatch negativity and P300 as candidate biomarkers of tinnitus presence and loudness. DISCUSSION: The identification of a biomarker for tinnitus is crucial for developing personalised diagnosis and treatment: There is a need for updated guidelines and more effective tinnitus treatments, as existing interventions often rely on subjective measures. The success of biomarkers like GPIAS and oddball paradigms could significantly improve the reliability of tinnitus diagnosis and treatment, marking a transformative step in the field. TRIAL REGISTRATION NUMBER: NCT06520865.

Indexed as

TinnitusAdultBiomarkersCase-Control StudiesChronic DiseaseElectroencephalographyEvoked PotentialsFemaleHumansMagnetoencephalographyMaleMiddle AgedProspective StudiesReflex, StartleResearch DesignSurveys and QuestionnairesBiomarkersAudiologyClinical ProtocolsNeurophysiology

Identifiers

PMID42156141
PMCPMC13202144

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.