ReviewGenes & development2026
A new perspective on ATR's role in translesion synthesis.
Review in Genes & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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0 citing papers in PubMed.
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Authors and funding
2 authors.
Funding
Abstract
During DNA replication, the physical and functional coupling of DNA unwinding by the CMG helicase with the DNA synthesis components of the replisome promotes highly efficient replication of the genome. What happens when the replication fork stalls at a DNA lesion? Do translesion synthesis (TLS) DNA polymerases operate in close coordination with the replisome or function independent of it; e.g., in daughter strand gaps? Using noncancer human cell lines, Yoon and colleagues (doi:10.1101/gad.353474.125) show that TLS operates in close coordination with the replisome and that ATR stabilizes the replisome at stalled replication forks; thus, TLS protects against chromosomal instability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.