ArticleTechnology in cancer research & treatment
Surface-Guided Radiation Therapy (SGRT) for Pediatric Oncology: An Analysis of Inter- and Intra-fraction Motion Variability and PTV Margins.
Article in Technology in cancer research & treatment. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
IntroductionTo quantify inter- and intra-fraction motion variability in pediatric radiotherapy using surface-guided radiation therapy (SGRT) and evaluate its impact on personalized planning target volume (PTV) margins.MethodsA retrospective analysis included 27 pediatric cancer patients (≤15 years old). Fourteen patients received conventional laser alignment based on skin markings (LAS group), while thirteen underwent SGRT for initial setup and continuous real-time intra-fraction monitoring. Inter-fraction errors were assessed using pre-treatment cone-beam CT (CBCT), and intra-fraction motion was captured via SGRT log files. Population systematic (Σ) and random (σ) errors were calculated. PTV margins compensating for setup uncertainties were derived using the van Herk formula. Dosimetric impact was evaluated by recalculating plans using SGRT-informed anisotropic margins compared to the applied 5 mm isotropic margins.ResultsSGRT improved inter-fraction setup accuracy over LAS, reducing median translational errors to 1.1 mm (lateral), 1.5 mm (longitudinal), and 1.7 mm (vertical), compared with 2.6 mm, 3.6 mm, and 1.9 mm (lateral/longitudinal,
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