Evidence map›Paper›PMID 42155999›Full record

ArticleJMIR mental health2026

Automated Safety Testing and Reporting Application for Conversational Safety Monitoring of Generative AI Tools for Mental Health: Development and Validation Study.

Daniel Szoke, Ilana Hutzler, Jerry Liu, Samantha Addante, Zuhaib Akhtar, Dale L Smith, Kirsten Dickins, Charles Small, Sarah Pridgen, Philip Held

Abstract readValidation Study
In one paragraph

Article in JMIR mental health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniel SzokeRush University Medical Center, Chicago, IL, United States.ORCID https://orcid.org/0000-0002-6777-3636
Ilana HutzlerRush University Medical Center, Chicago, IL, United States.ORCID https://orcid.org/0009-0000-3959-7893
Jerry LiuRush University Medical Center, Chicago, IL, United States.ORCID https://orcid.org/0009-0001-1778-0125
Samantha AddanteRush University Medical Center, Chicago, IL, United States.ORCID https://orcid.org/0009-0000-0213-9936
Zuhaib AkhtarRush University Medical Center, Chicago, IL, United States.ORCID https://orcid.org/0000-0002-0338-6549
Dale L SmithRush University Medical Center, Chicago, IL, United States.ORCID https://orcid.org/0000-0003-0854-9973
Kirsten DickinsRush University Medical Center, Chicago, IL, United States.ORCID https://orcid.org/0000-0003-4029-8932
Charles SmallRush University Medical Center, Chicago, IL, United States.ORCID https://orcid.org/0009-0003-4941-4714
Sarah PridgenRush University Medical Center, Chicago, IL, United States.ORCID https://orcid.org/0000-0002-2640-8050
Philip HeldRush University Medical Center, Chicago, IL, United States.ORCID https://orcid.org/0000-0003-3974-1802

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundArtificial intelligence (AI)-based conversational tools are rapidly expanding within mental health care as a means of increasing access and scalability. At the same time, these systems introduce distinct safety risks arising from both user disclosures (eg, self-harm ideation) and inappropriate or inadequate AI responses.

objectiveThis study aimed to develop and evaluate the Automated Safety Testing and Reporting Application (ASTRA), an external system intended to identify clinically relevant risk behaviors across entire AI-mediated mental health conversations.

methodsASTRA was tested on a dataset of 100 synthetic therapeutic conversations written by licensed clinicians to reflect risk behaviors and harmful responses between users and AI tools. Conversations varied in length and included both subtle and overt risk behavior examples across 8 predefined categories. Human coder consensus ratings served as the reference standard. ASTRA's classifications were evaluated across 2 prompt iterations using standard diagnostic performance metrics and agreement statistics.

resultsASTRA demonstrated consistently high concordance with expert human ratings across all categories. Accuracy exceeded 0.90 for all risk behavior categories examined, with specificity uniformly high and sensitivity varying by category (range 0.55-1.00). Agreement beyond chance was substantial to almost perfect between ASTRA and human raters (κ=0.65-1.00). Detection of user self-harm indicators was particularly accurate, even in conversations where risk was expressed subtly.

conclusionsIn this initial validation study, ASTRA reliably identified multiple forms of mental health-related risk behaviors at the conversation level. These findings support the feasibility of independent safety monitoring systems as a complement to AI tools used in mental health contexts and underscore the need for further evaluation using larger and real-world datasets.

Indexed as

Artificial IntelligenceCommunicationPatient SafetyRisk-TakingGenerative Artificial IntelligenceHumansAIartificial intelligenceautomated monitoringlarge language modelssafetysuicide risk

Identifiers

PMID42155999
PMCPMC13231103

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.