ArticlePreventing chronic disease2026
Sit-to-Stand Performance, Moderate-to-Vigorous Physical Activity, and Health-Related Quality of Life in Knee Osteoarthritis: A Prospective Mediation Analysis.
Article in Preventing chronic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Relative Sit-to-Stand Power Versus Conventional Sit-to-Stand Time in the Clinical Assessment of Older Adults at Risk of Falls.Healthcare (Basel, Switzerland) · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Knee osteoarthritis (KOA) is the most common form of arthritis, leading to illness, decreased physical function, and reduced health-related quality of life (HR-QoL). Sit-to-stand (STS) testing is a commonly used measure of physical capacity in KOA. This study examined whether STS performance and moderate-to-vigorous physical activity (MVPA) helped account for the association between KOA pain and subsequent HR-QoL. Methods: Data across 2 years (at year 6 and year 8 visits) were used from the Osteoarthritis Initiative (OAI), a multisite, longitudinal study of people with or at risk for KOA. We used serial mediation analysis to examine whether year 6 STS performance and year 8 MVPA accounted for the association between year 6 KOA pain and year 8 HR-QoL, adjusting for age, sex, and race. Results: Significant correlations among all model variables supported model testing. The serial mediation model revealed that an increase in KOA pain predicted worse STS performance (β = .15; P < .001). MVPA was reduced by an increase in KOA pain (β = -.13; P < .001) but not STS (β = -.02; P = .46). MVPA subsequently predicted HR-QoL (β = .12; P < .001). The overall indirect pathway was significant (β = -0.02; 95% CI, -0.040 to -0.009), but the direct pathway also remained significant (β = -0.47; 95% CI, -0.536 to -0.410), denoting a partial mediation effect. Conclusion: STS performance and MVPA partially mediated the relationship between KOA pain and HR-QoL, highlighting mechanisms to address in future interventions for improving HR-QoL. These results support STS as a complementary tool to pain for understanding MVPA participation and HR-QoL in KOA patients. The findings also underscore the importance of integrating self-management strategies to address pain in behavior-change interventions.
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