Evidence map›Paper›PMID 42155964›Full record

ArticleJournal of medicinal chemistry2026

Targeting Multiple KRAS Mutations with High-Affinity Macrocyclic Inhibitors: From Discovery to Preclinical Validation.

Dean P Phillips, Phil B Alper, Charles Y Cho, Dmitry Borkin, Dong Han, Sarah E Kochanek, Agnes Vidal-Biggart, Ananda Herath, Jitendra Gurjar, Wenshuo Lu and 64 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

74 authors.

Dean P PhillipsNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.ORCID 0009-0001-8944-4139
Phil B AlperNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.ORCID 0000-0002-4115-0633
Charles Y ChoNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Dmitry BorkinNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Dong HanNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Sarah E KochanekNovartis Biomedical Research, Cambridge, Massachusetts 02139, United States.ORCID 0000-0001-6213-8476
Agnes Vidal-BiggartNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Ananda HerathNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Jitendra GurjarNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Wenshuo LuNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Casey J N MathisonNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
John M NelsonNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Wei PeiNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Shanshan YanNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Bao Ngoc NguyenNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Timothy HoffmanNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Barun OkramNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Truc N NguyenNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Songchun JiangNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Brian T MasickNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Zhicheng WangNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Victor NikulinNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Hong YinNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Yu ChenNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Jose JuarezNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Yelena SarkisovaNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Yong JiaNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Vicki ZhouNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Guoxun LiuNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Xianzhong LiuNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Min LuNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Brandon L TaylorNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Lang HuynhNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Yu WangNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Reynand PacomaNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Janine BaatenNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Kathryn TopolewskiNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Clifford WrightNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Trish NguyenNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Deborah A KneeNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Qian LiuNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Jun LiuNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Jie LiNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Cyrus VirataNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Sergio BrionesNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Michael DiDonatoNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.ORCID 0000-0002-9074-7284
Badry BursulayaNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
David H JonesNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Darbi WitmerNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Carolyn ChuNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Hong JinNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Wendy RichmondNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Lucas WestlingNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Thomas HollenbeckNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Ashley ChongNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Sally FraneyNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Todd GroesslNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Michael ShapiroNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Kathleen EffenbergerNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Konrad ArroyoNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Angela BretzNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.ORCID 0000-0001-9309-9588
Ayako HondaNovartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
James BrownNovartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
Carina C SanchezNovartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
William P GordonNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Jason T MatzenNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Nils OstermanNovartis Biomedical Research, Basel CH-4056, Switzerland.ORCID 0000-0002-3391-1228
Simona CotestaNovartis Biomedical Research, Basel CH-4056, Switzerland.ORCID 0000-0002-4089-2213
Saskia M BrachmannNovartis Biomedical Research, Basel CH-4056, Switzerland.
Rainer WilckenNovartis Biomedical Research, Basel CH-4056, Switzerland.ORCID 0000-0002-6159-1460
Frederic ZecriNovartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
Kim S BeyerNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.ORCID 0000-0002-3047-304X
Valentina MolteniNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Jacob R HalingNovartis Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The RAS Switch-II pockets' discovery enabled targeting a challenging molecular site. Covalent KRAS

Indexed as

Antineoplastic AgentsMacrocyclic CompoundsMutationProto-Oncogene Proteins p21(ras)AnimalsCell Line, TumorDrug DiscoveryHumansMiceModels, MolecularStructure-Activity RelationshipXenograft Model Antitumor AssaysAntineoplastic AgentsKRAS protein, humanMacrocyclic CompoundsProto-Oncogene Proteins p21(ras)

Identifiers

PMID42155964
PMCPMC13267867

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.