ArticleNeuron2026
Precision fMRI reveals densely interdigitated network patches with conserved motifs in the lateral prefrontal cortex.
Article in Neuron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Separate dorsolateral prefrontal cortex regions participate in distinct large-scale networks differentially recruited for social and cognitive control functions.Journal of neurophysiology · 2026Article
- Frontoparietal Hub Connectivity Integrates Information from Multiple Sources.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Feasibility of precision functional mapping in youth multi-echo fMRI data.Developmental cognitive neuroscience · 2026Article
- Functional brain organization is stable within individuals across years.bioRxiv : the preprint server for biology · 2026Article
- Individualized parcellation reveals functional boundaries in human prefrontal cortex.bioRxiv : the preprint server for biology · 2026Article
- Article
- Frontoparietal Hub Connectivity Integrates Information from Multiple Sources.bioRxiv : the preprint server for biology · 2026Article
- Parallel processing chains span cytoarchitectures to organize association cortex.bioRxiv : the preprint server for biology · 2026Article
- Commonality and Variability in Functional Networks in Children Under 5 Years Old.bioRxiv : the preprint server for biology · 2026Article
- Dense Phenotyping of Human Brain Network Organization Using Precision fMRI.Annual review of psychology · 2026Review
- Adjacent Dorsolateral Prefrontal Cortex (DLPFC) Regions Participate in Distinct Large-Scale Networks Differentially Recruited for Social and Cognitive Control Functions.bioRxiv : the preprint server for biology · 2025Article
- A distinct set of brain areas process prosody-the melody of speech.bioRxiv : the preprint server for biology · 2025Article
- Old-New Recognition Memory Revisited.bioRxiv : the preprint server for biology · 2025Article
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13 authors.
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Abstract
Dominant models of human lateral prefrontal cortex (LPFC) organization emphasize broad domain-general zones and smooth functional gradients. However, these models rely on group-averaged neuroimaging, which can obscure fine-scale cortical features in highly inter-individually variable regions such as the LPFC. To address this limitation, we collected a new precision fMRI dataset from 10 individuals, each with approximately 2 h of resting-state fMRI and 6 h of task fMRI data. We mapped individual-specific LPFC networks using resting-state data and tested network-level functional preferences using task data. We found that individual LPFC networks showed fragmented and interdigitated organization compared to the group-averaged networks, including novel conserved motifs present across individuals. Task fMRI revealed that distinct yet adjacent networks support domain-specific processes (i.e., language, social cognition, and episodic projection) versus domain-general cognitive control. Sharp functional boundaries were visible at the individual level that could not be observed in group data. These findings uncover previously hidden fine-scale organizational principles present in the LPFC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.