Evidence map›Paper›PMID 42155442›Full record

ArticleCell genomics2026

Synthetic rewriting of the IGH locus.

Zong-Heng Fu, Yuan Ma, Si Cheng, Yuan Zhong, Nan Wang, Zhaoqing Ba, Guang-Rong Zhao, Yi Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zong-Heng FuState Key Laboratory of Synthetic Biology, Tianjin University, Tianjin 300072, China; Frontiers Science Center for Synthetic Biology (Ministry of Education), School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin 300072, China.
Yuan MaState Key Laboratory of Synthetic Biology, Tianjin University, Tianjin 300072, China; Frontiers Science Center for Synthetic Biology (Ministry of Education), School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin 300072, China.
Si ChengState Key Laboratory of Synthetic Biology, Tianjin University, Tianjin 300072, China; Frontiers Science Center for Synthetic Biology (Ministry of Education), School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin 300072, China.
Yuan ZhongState Key Laboratory of Synthetic Biology, Tianjin University, Tianjin 300072, China; Frontiers Science Center for Synthetic Biology (Ministry of Education), School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin 300072, China.
Nan WangState Key Laboratory of Synthetic Biology, Tianjin University, Tianjin 300072, China; Frontiers Science Center for Synthetic Biology (Ministry of Education), School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin 300072, China.
Zhaoqing BaNational Institute of Biological Sciences, Beijing 102206, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 100084, China.
Guang-Rong ZhaoState Key Laboratory of Synthetic Biology, Tianjin University, Tianjin 300072, China; Frontiers Science Center for Synthetic Biology (Ministry of Education), School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin 300072, China. Electronic address: grzhao@tju.edu.cn.
Yi WuState Key Laboratory of Synthetic Biology, Tianjin University, Tianjin 300072, China; Frontiers Science Center for Synthetic Biology (Ministry of Education), School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin 300072, China. Electronic address: yi.wu@tju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

V(D)J recombination, which joins V, D, and J genes across immunoglobulin loci, is essential for antibody diversity. To unlock the inherent constraints of V(D)J recombination, we systematically designed, assembled, and shuffled a synthetic human immunoglobulin heavy chain locus (SynIgh). SynIgh was designed de novo, incorporating 60 V

Indexed as

Immunoglobulin Heavy ChainsV(D)J RecombinationAnimalsGenetic LociHumansMiceImmunoglobulin Heavy Chainsgenome engineeringsynthetic biologysynthetic genomicsV(D)J recombination

Identifiers

PMID42155442
PMCPMC13261652

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.