Evidence map›Paper›PMID 42155368›Full record

ArticleUltrasonics sonochemistry2026

Ultrasound-assisted size tuning of polyacrylic acid coated magnetic nanoparticle clusters for biomedical applications.

Lukas Heinen, Pascal-Raphael Blersch, Constantin Schnell, Karsten Meyer, Roland Nagy, Marcus Halik, Christina Janko, Stefan Lyer, Christoph Alexiou, Rainer Tietze

Abstract read
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In one paragraph

Article in Ultrasonics sonochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lukas HeinenDepartment of Otorhinolaryngology - Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner Fresenius Foundation Professorship (EKFS), Universitätsklinikum Erlangen, Erlangen, 91054, Bavaria, Germany; Organic Materials & Devices, Institute of Polymer Materials, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058, Bavaria, Germany. Electronic address: lukas.heinen@uk-erlangen.de.
Pascal-Raphael BlerschDepartment of Otorhinolaryngology - Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner Fresenius Foundation Professorship (EKFS), Universitätsklinikum Erlangen, Erlangen, 91054, Bavaria, Germany.
Constantin SchnellDepartment of Chemistry and Pharmacy, Inorganic Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058, Bavaria, Germany.
Karsten MeyerDepartment of Chemistry and Pharmacy, Inorganic Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058, Bavaria, Germany.
Roland NagyInstitute of Applied Quantum Technologies, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91052, Bavaria, Germany.
Marcus HalikOrganic Materials & Devices, Institute of Polymer Materials, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058, Bavaria, Germany.
Christina JankoDepartment of Otorhinolaryngology - Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner Fresenius Foundation Professorship (EKFS), Universitätsklinikum Erlangen, Erlangen, 91054, Bavaria, Germany.
Stefan LyerDepartment of Otorhinolaryngology - Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner Fresenius Foundation Professorship (EKFS), Universitätsklinikum Erlangen, Erlangen, 91054, Bavaria, Germany.
Christoph AlexiouDepartment of Otorhinolaryngology - Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner Fresenius Foundation Professorship (EKFS), Universitätsklinikum Erlangen, Erlangen, 91054, Bavaria, Germany.
Rainer TietzeDepartment of Otorhinolaryngology - Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner Fresenius Foundation Professorship (EKFS), Universitätsklinikum Erlangen, Erlangen, 91054, Bavaria, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hydrodynamic size of magnetic nanoparticle clusters is a critical determinant of their in vivo behaviour and therapeutic efficacy. While alkaline co-precipitation offers a scalable route for polyacrylic acid (PAA) coated superparamagnetic iron oxide nanoparticles (SPIONs), it typically yields polydisperse agglomerates. This work establishes a predictive engineering process using controlled, post-synthesis ultrasound treatment to precisely tune SPION cluster size. Utilising a D-optimal Design of Experiments (DoE) approach, we modelled the influences of sonication parameters on the hydrodynamic diameter, identifying specific energy input as the governing factor for de-agglomeration. The resulting verified regression model (adj. R

Indexed as

Acrylic ResinsMagnetite NanoparticlesParticle SizeUltrasonic WavesAnimalsCell Line, TumorHydrodynamicsMiceAcrylic Resinscarbopol 940Magnetite NanoparticlesCellular loadingMagnetic nanoclustersSize tunabilityUltrasound

Identifiers

PMID42155368
PMCPMC13213284

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.