Evidence map›Paper›PMID 42154979›Full record

ArticleInflammatory bowel diseases2026

Clinicopathological features and cancer-specific survival in young patients with ulcerative colitis-associated colorectal neoplasia: a nationwide cohort study in Japan.

Takahide Shinagawa, Koichi Komatsu, Motoi Uchino, Hiroki Ikeuchi, Kohei Shigeta, Shiro Oka, Daijiro Higashi, Shimpei Ogawa, Kazuhiro Watanabe, Masatsune Shibutani and 34 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammatory bowel diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors.

Takahide ShinagawaDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.ORCID 0000-0003-3790-7047
Koichi KomatsuDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Motoi UchinoDepartment of Inflammatory Bowel Disease Surgery, Hyogo Medical University, Nishinomiya, Japan.ORCID 0000-0002-2934-1680
Hiroki IkeuchiDepartment of Inflammatory Bowel Disease Surgery, Hyogo Medical University, Nishinomiya, Japan.
Kohei ShigetaDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.ORCID 0000-0003-1596-4200
Shiro OkaDepartment of Gastroenterology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Daijiro HigashiDepartment of Surgery, Fukuoka University Chikushi Hospital, Chikushino, Japan.
Shimpei OgawaDepartment of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
Kazuhiro WatanabeDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Masatsune ShibutaniDepartment of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Yoshiki OkitaDepartment of Gastrointestinal and Pediatric Surgery, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Japan.ORCID 0000-0001-8040-4854
Toshifumi WakaiDivision of Digestive and General Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.ORCID 0000-0003-2443-3428
Yusuke MizuuchiDepartment of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kinya OkamotoDepartment of Coloproctology, Tokyo Yamate Medical Center, Tokyo, Japan.
Kazutaka YamadaDepartment of Surgery, Coloproctology Center Takano Hospital, Kumamoto, Japan.ORCID 0000-0003-1385-3347
Yu SatoDepartment of Surgery, Toho University Sakura Medical Center, Chiba, Japan.
Takayuki OginoDepartment of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
Hideaki KimuraInflammatory Bowel Disease Center, Yokohama City University Medical Center, Yokohama, Japan.
Kenichi TakahashiDepartment of Colorectal Surgery, Tohoku Rosai Hospital, Sendai, Japan.
Koya HidaDepartment of Surgery, Kyoto University Hospital, Kyoto, Japan.ORCID 0000-0001-7210-7075
Yusuke KinugasaDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, Tokyo, Japan.
Fumio IshidaDigestive disease center, Showa University Northern Yokohama Hospital, Kanagawa, Japan.
Junji OkudaDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Koji DaitoDepartment of Surgery, Faculty of Medicine, Kindai University, Osaka, Japan.
Takayuki YamamotoInflammatory Bowel Disease Center, Yokkaichi Hazu Medical Center, Yokkaichi, Japan.
Seiichiro YamamotoDepartment of Gastroenterological Surgery, Tokai University School of Medicine, Tokyo, Japan.
Fumikazu KoyamaDepartment of Surgery, Nara Medical University, Nara, Japan.ORCID 0000-0002-2775-908X
Junichiro HiroDepartment of Surgery, Fujita Health University, School of Medicine, Aichi, Japan.
Koji KomoriDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Aichi, Japan.
Dai ShidaDepartment of Surgery, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.ORCID 0000-0003-3294-1924
Junya ArakakiCenter for Gastroenterology, Department of Surgery, Urasoe General Hospital, Okinawa, Japan.
Fumihiko FujitaDepartment of Surgery, Kurume University Hospital, Kurume, Japan.
Takatoshi MatsuyamaDepartment of Digestive Tract and General Surgery, Saitama Medical Center, Saitama, Japan.
Hideki UenoDepartment of Surgery, National Defense Medical College, Tokorozawa, Japan.ORCID 0000-0002-8600-1199
Hiroki OchiaiDepartment of Surgery, Teikyo University School of Medicine, Tokyo, Japan.
Atsuo MaemotoInflammatory Bowel Disease Center, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan.
Riichiro NezuDepartment of Surgery, Nishinomiya Municipal Central Hospital, Nishinomiya, Japan.ORCID 0000-0003-4489-4272
Shin SasakiDepartment of Coloproctological Surgery, Japanese Red Cross Medical Center, Tokyo, Japan.
Eiji SunamiDepartment of Surgery, Kyorin University, Tokyo, Japan.
Tatsuki NoguchiDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.ORCID 0000-0003-1297-0699
Kenichi SugiharaInstitute of Science Tokyo, Tokyo, Japan.
Yoichi AjiokaDepartment of Pathology, Niigata University, Niigata, Japan.
Soichiro IshiharaDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.ORCID 0000-0003-0543-0045
Study Group for Inflammatory Bowel Disease Associated Intestinal Cancers by Japanese Society for Cancer of the Colon and Rectum

Funding

Colon and RectumJapanese Society for CancerJapanese Society for Cancer of the Colon and Rectum
6 · The paper itself

Abstract

backgroundThe incidence of ulcerative colitis-associated colorectal neoplasia (UCAN) is increasing, but clinicopathological features and outcomes in young patients remain unclear. We aimed to clarify the characteristics and survival of UCAN diagnosed before the age of 40 using years in a nationwide Japanese cohort study conducted by the Japanese Society for Cancer of the Colon and Rectum.

methodsWe retrospectively analyzed 1212 patients with UCAN treated at 43 institutions in Japan during the period from 1983 to 2020. Patients were categorized as young (<40 years) or non-young (≥40 years). Clinicopathological features, cancer-specific survival (CSS), relapse-free survival (RFS), and survival after recurrence (SAR) were compared.

resultsYoung-onset UCAN accounted for 252 patients (20.8%) and showed a shorter interval from UC onset to carcinogenesis (14.0 vs 17.0 years; P < .001), more frequent pancolitis (81.3% vs 74.8%; P = .012), and a higher proportion of poorly differentiated, mucinous, or signet-ring cell carcinoma (20.2% vs 13.3%; P < .001). Five-year CSS was significantly lower in young patients (85.1% vs 89.8%; P = .039), whereas RFS was comparable (86.2% vs 86.3%; P = .750). Minimally invasive surgery (MIS) was independently associated with improved CSS (hazard ratio [HR], 0.593; 95% CI, 0.356-0.987; P = .045). The SAR remained poor in both age groups (23.6% vs 28.5%; P = .468).

conclusionsWhen diagnosed in patients aged <40 years, UCAN is characterized by earlier carcinogenesis, extensive disease, and aggressive histology, with worse CSS. The potential role of MIS in improving prognosis warrants further prospective investigation, while the outcome of SAR remains poor irrespective of patient age.

Indexed as

Colitis-Associated NeoplasmsColitis, UlcerativeColorectal NeoplasmsNeoplasm Recurrence, LocalAdultAge of OnsetCarcinoma, Signet Ring CellCohort StudiesFemaleHumansJapanMaleMiddle AgedPrognosisRetrospective StudiesSurvival Ratecolitis-associated colorectal neoplasiacolorectal cancerinflammatory bowel diseaseulcerative colitisyoung-onset

Identifiers

PMID42154979
PMCPMC13533184

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.