Evidence map›Paper›PMID 42154963›Full record

ReviewHuman vaccines & immunotherapeutics2026

Safety of COVID-19 mRNA-1273 booster doses in Asian populations: A literature review of post-marketing observational studies.

Chris Clarke, Daina Esposito, Veronica Urdaneta, Piyali Mukherjee, Amanda K Buttery

Abstract readReview
In one paragraph

Review in Human vaccines & immunotherapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chris ClarkeModerna, Melbourne, Australia.
Daina EspositoModerna, Inc., Cambridge, MA, USA.
Veronica UrdanetaModerna, Inc., Cambridge, MA, USA.ORCID 0009-0009-9215-3541
Piyali MukherjeeModerna, Singapore, Singapore.
Amanda K ButteryModerna, Melbourne, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Real-world data on the safety of COVID-19 booster doses in Asian populations are needed to inform national immunization programs. The safety profile of mRNA-1273 (Moderna, Inc.) was evaluated using post-marketing observational data. PubMed and EMBASE were searched on June 30, 2025, for studies meeting the following predefined criteria: observational design, adverse events (AEs), mRNA-1273 boosters (dose 3+), and population data from the South-East Asia and Western-Pacific regions. Data on study characteristics, and AE incidence and severity, were extracted. Of 886 records screened, 27 studies from eight countries (Japan, the Republic of Korea, Australia, Taiwan, Indonesia, Thailand, the Philippines, and Singapore) met the inclusion criteria. Across studies, mRNA-1273 boosters were well tolerated, with severe AEs occurring at low frequency. Based on the included observational studies, these findings support the favorable safety profile of mRNA-1273 boosters in Asian populations. Long-term safety monitoring is needed to guide public-health responses to evolving SARS-CoV-2 variants.

Indexed as

2019-nCoV Vaccine mRNA-1273COVID-19COVID-19 VaccinesImmunization, SecondaryAsiaAsian PeopleHumansObservational Studies as TopicProduct Surveillance, Postmarketing2019-nCoV Vaccine mRNA-1273COVID-19 Vaccinesadverse eventboosterCOVID-19literature reviewmRNAmRNA-1273safetySARS-CoV-2vaccine

Identifiers

PMID42154963
PMCPMC13192099

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.