Observational studyEinstein (Sao Paulo, Brazil)2026
Translation, cross-cultural adaptation, and validation of the Lung Transplant Quality of Life (LT-QOL) questionnaire for use in adult patients after lung transplantation into Portuguese Brazilian.
Observational study in Einstein (Sao Paulo, Brazil), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
objectiveTo translate, cross-culturally adapt, and validate the Lung Transplant Quality of Life questionnaire into Brazilian Portuguese.
methodsThis observational study enrolled 50 participants. Translation and cross-cultural adaptation were conducted in accordance with established guidelines for self-report measures and the Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN). The measurement properties assessed included internal consistency, agreement, intra-rater reliability, and convergent validity. Convergent validity was evaluated by comparing the Lung Transplant Quality of Life with the Short Form Health Survey (SF-36) and the Saint George's Respiratory Questionnaire.
resultsThe Lung Transplant Quality of Life showed adequate internal consistency (Cronbach's alpha=0.86) and excellent intra-rater reliability (intraclass correlation coefficient=0.93). Agreement analysis yielded a standard error of measurement of 8.72. Bland-Altman analysis revealed low mean differences (0.8) between Lung Transplant Quality of Life scores and acceptable limits of agreement (95%CI=-16.9-15.3). Spearman's correlation showed excellent convergent validity with the SF-36 and good validity with the Saint George's Respiratory Questionnaire in both test and retest phases.
conclusionThe Brazilian Portuguese version of the Lung Transplant Quality of Life is a valid and reliable instrument for assessing health-related quality of life in lung transplant patients. Further research is warranted to develop a shorter version while preserving its measurement properties.
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