In one paragraphArticle in Science signaling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Bhagwati JoshiDepartment of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.ORCID 0009-0001-7770-8408 Jagdish Chandra JoshiDepartment of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.ORCID 0000-0002-9468-3046 Vijay Avin Balaji RaghunathraoDepartment of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Vigneshwaran VelligiriDepartment of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.ORCID 0000-0003-3695-7384 Md Zahid AkhterDepartment of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.ORCID 0000-0002-1602-3704 Peter T TothDepartment of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.ORCID 0000-0003-2168-0124 Tejabhiram YadavalliDepartment of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, Chicago, IL 60612, USA.ORCID 0000-0001-8584-2685 Josh ThompsonDepartment of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.ORCID 0000-0002-3733-2477 Somenath BanerjeeDepartment of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.ORCID 0000-0002-1527-7550 Deepak ShuklaDepartment of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, Chicago, IL 60612, USA.ORCID 0000-0002-3039-6953 Vadim GaponenkoDepartment of Biochemistry and Molecular Genetics, University of Illinois College of Medicine, Chicago, IL 60612, USA.ORCID 0000-0002-7891-9223 Yulia KomarovaDepartment of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.ORCID 0000-0002-3526-6082 Dolly MehtaDepartment of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.ORCID 0009-0001-7770-8408 Funding
The Lung Endothelium as an Instructive Niche for the Innate Immune System during Vascular InjuryP01HL160469 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DOLLY MEHTA · 2022 to 2026
$14.0MSynthetic Biology and Optogenetics CoreP01HL151327 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MEHTA, DOLLY · 2021 to 2025
$11.8MFocal Adhesion Kinase Regulation of Lung Vascular Permeability and EdemagenesisR01HL084153 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MEHTA, DOLLY · 2007 to 2022
$5.4MTargeting mechanisms activating ion-channel for preventing acute lung injuryR01HL165263 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DOLLY MEHTA · 2023 to 2026
$2.4MCREB Instruction of Macrophage Fate and Lung fluid homeostasisR01HL155941 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MEHTA, DOLLY · 2021 to 2024
$636kNHLBI NIH HHS P01 HL151327NHLBI NIH HHS P01 HL160469NHLBI NIH HHS R01 HL084153NHLBI NIH HHS R01 HL155941NHLBI NIH HHS R01 HL165263
6 · The paper itselfAbstract
An uncontrolled innate immune response to pathogens in the lung causes acute lung injury, in which the cytosolic double-stranded DNA (dsDNA) sensor, cyclic GMP-AMP synthase (cGAS), and its induction of interferon-β (IFN-β) play a crucial role. Given that the vascular endothelium is a point of host contact for both environmental and blood-borne pathogens, we investigated the response of cGAS to dsDNA in endothelial cells in regulating innate immunity in the lung. We found that the phosphorylation of Tyr
Indexed as
Immunity, InnateLungMyosin Light ChainsNucleotidyltransferasesAnimalscGAS-STING Signaling PathwayCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDNAHumansInterferon-betaMiceMice, Inbred C57BLMice, KnockoutPhosphorylationPseudomonas aeruginosaPseudomonas InfectionscGAS protein, humancGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDNAInterferon-betaMyosin Light ChainsNucleotidyltransferasesTyrosine
Identifiers
PMID42154837
PMCPMC13681457
What OpenQuestion holds
Textmetadata
Read underepoch 390