Evidence map›Paper›PMID 42154827›Full record

Trial reportBrazilian oral research2026

Effect of strict oral hygiene on self-rated halitosis and quality of life in patients with periodontitis: a secondary randomized controlled trial analysis.

Bruno Ferraz Barbosa da Costa, Vanessa Feitosa Alves, Luísa Schertel Cassiano, Gustavo Giacomelli Nascimento, Valeska Maria Souto Paiva, Lívia Valéria Lins E Silva, Sabrina Garcia de Aquino

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Brazilian oral research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bruno Ferraz Barbosa da CostaUniversidade Federal da Paraíba - UFPB, Department of Clinical and Social Dentistry, João Pessoa, PB, Brazil.ORCID http://orcid.org/0000-0003-4334-8608
Vanessa Feitosa AlvesUniversidade Federal da Paraíba - UFPB, Department of Clinical and Social Dentistry, João Pessoa, PB, Brazil.ORCID http://orcid.org/0000-0002-6676-9037
Luísa Schertel CassianoAarhus University, Department of Dentistry and Oral Health, Section for Periodontology, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-2976-1386
Gustavo Giacomelli NascimentoNational Dental Research Institute Singapore, National Dental Centre Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-4288-6300
Valeska Maria Souto PaivaUniversidade Federal da Paraíba - UFPB, Department of Clinical and Social Dentistry, João Pessoa, PB, Brazil.ORCID http://orcid.org/0000-0001-5856-2928
Lívia Valéria Lins E SilvaUniversidade Federal da Paraíba - UFPB, Department of Clinical and Social Dentistry, João Pessoa, PB, Brazil.ORCID http://orcid.org/0000-0002-2510-7846
Sabrina Garcia de AquinoUniversidade Federal da Paraíba - UFPB, Department of Clinical and Social Dentistry, João Pessoa, PB, Brazil.ORCID http://orcid.org/0000-0002-3988-1939

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This single-blind, randomized clinical trial evaluated the impact of a strict oral hygiene (OH) phase on self-reported halitosis and quality of life (QoL) in patients with periodontitis. This study reports a secondary analysis of a single-blind randomized controlled trial (parallel, 1:1), registered at RBR-5jmx32v. The study included 24 individuals diagnosed with periodontitis who were randomly assigned to the intervention group (IG; n = 12) and the no-intervention group (NIG; n = 12). After receiving personalized OH instructions, the IG participants followed a rigorous OH phase for 45 days, whereas the NIG participants received no guidance during this period. The halitosis-associated QoL test (HALT) was administered at baseline and after 45 days. Data were analyzed using t-tests, chi-square tests, and multilevel linear regression, with significance set at p < 0.05. The average age of the study participants was 47.2 years, with a balanced sex distribution and no differences in income or education. Self-reported halitosis decreased from 100% to 50% in the IG after 45 days, whereas it remained at 91.6% in the NIG (p = 0.034). The IG also showed a mean HALT score reduction of 11.9 points (-11.88; 95% CI: -19.40 to -4.36), with significant improvements in social impact and self-esteem (p < 0.05). Clinically, BOP (p < 0.001) and VPI (p = 0.03) improved significantly in the IG, with no significant changes in NIG. This exploratory trial demonstrates that implementing a strict OH phase in patients with periodontitis may help reduce self-reported halitosis, improve HALT scores, and improve clinical outcomes, supporting its role as an adjunctive strategy in periodontal care.

Indexed as

HalitosisOral HygienePeriodontitisQuality of LifeAdultFemaleHumansMaleMiddle AgedSelf ReportSingle-Blind MethodTime FactorsTreatment Outcome

Identifiers

PMID42154827
PMCPMC13185520

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.