Evidence map›Paper›PMID 42154822›Full record

ArticleeLife2026

Lineage priming and cell type proportioning depends on the interplay between stochastic and deterministic factors.

William Salvidge, Chris Brimson, Nicole Gruenheit, Li-Yao Huang, Catherine Pears, Jason Wolf, Chris Thompson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

William SalvidgeCentre for Life's Origins and Evolution, Department of Genetics, Evolution and Environment, University College London, London, United Kingdom.
Chris BrimsonCentre for Life's Origins and Evolution, Department of Genetics, Evolution and Environment, University College London, London, United Kingdom.
Nicole GruenheitCentre for Life's Origins and Evolution, Department of Genetics, Evolution and Environment, University College London, London, United Kingdom.
Li-Yao HuangDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom.
Catherine PearsDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom.
Jason WolfMilner Centre for Evolution and Department of Life Sciences, University of Bath, Bath, United Kingdom.ORCID https://orcid.org/0000-0003-3112-6602
Chris ThompsonCentre for Life's Origins and Evolution, Department of Genetics, Evolution and Environment, University College London, London, United Kingdom.ORCID https://orcid.org/0000-0002-5240-2592

Funding

Natural Environment Research Council NE/V012002/1Wellcome 10.35802/095643
6 · The paper itself

Abstract

Isogenic cells can break symmetry and adopt different fates, even when exposed to a seemingly identical environment. This deeply conserved phenomenon allows unicellular organisms to pre-empt dynamically changing environments and is central to the evolution of multicellularity. It is thought that cells are primed towards different lineages by cell-cell variation, although the underlying mechanisms are poorly understood. To address this, we exploit the tractability of the social amoeba

Indexed as

Cell DifferentiationCell LineageDictyosteliumHistonesModels, BiologicalSingle-Cell Gene Expression AnalysisStochastic ProcessesHistonescell fatechromosomesdevelopmental biologydictyosteliumDictyosteliumgene expressionhistone modificationstochastic

Identifiers

PMID42154822
PMCPMC13186565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.