ArticleInternational archives of allergy and immunology2026
Threshold Concentration of Ragweed Pollen for Inducing Allergic Symptoms: Initial Data Using an Allergen Challenge Chamber.
Article in International archives of allergy and immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionClimate change may increase the spread of allergenic plants such as ragweed. Ragweed pollen is assumed to be more allergenic than birch pollen. Determining pollen threshold concentrations triggering symptoms is challenging. Technical modifications to the Fraunhofer allergen challenge chamber (ACC) now allow investigation of very low pollen concentrations. Based on Total Nasal Symptom Score (TNSS) data from 15 subjects with birch pollen allergic rhinitis (AR), a birch pollen threshold between 50 and 100 pollen grains/m3 of air was previously derived. This study explored threshold concentrations of ragweed pollen.
methodsTwo ragweed pollen AR patients were exposed to varying concentrations of ragweed pollen for 4 h. TNSS was recorded every 20 min, and nasal secretion and peak nasal inspiratory flow hourly. Area under the curve (AUC
resultsRagweed pollen exposure resulted in the following TNSS AUC
conclusionThe modified Fraunhofer ACC can investigate pollen threshold concentrations under defined conditions. The assumed differences in threshold concentrations of ragweed and birch pollen for triggering symptoms were not confirmed. To derive reliable threshold concentrations for ragweed pollen, larger studies have to be followed.
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