Evidence map›Paper›PMID 42154384›Full record

ArticleActa parasitologica2026

In Vitro and In Vivo Study of Green-Synthesized Zinc Oxide Nanoparticles as a Novel Anticoccidial Agent.

Shaimaa M Kasem, Nabila M Mira, Mohamed A Dkhil, Heba Ismaeil, Saeed El-Ashram, Andreas Meryk, Hend M Alharbi, Rewaida Abdel-Gaber

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Article in Acta parasitologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shaimaa M KasemZoology Department, Faculty of Science, Kafrelsheikh University, Kafr Elsheikh, 33516, Egypt.
Nabila M MiraZoology Department, Faculty of Science, Kafrelsheikh University, Kafr Elsheikh, 33516, Egypt.
Mohamed A DkhilZoology and Entomology Department, Faculty of Science, Capital University, Cairo, 11759, Egypt.
Heba IsmaeilZoology Department, Faculty of Science, Kafrelsheikh University, Kafr Elsheikh, 33516, Egypt.
Saeed El-AshramZoology Department, Faculty of Science, Kafrelsheikh University, Kafr Elsheikh, 33516, Egypt.
Andreas MerykDepartment of Pediatrics, Medical University of Innsbruck, Innsbruck, Austria.
Hend M AlharbiDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, 11671, Riyadh, Saudi Arabia.
Rewaida Abdel-GaberDepartment of Zoology, College of Science, King Saud University, 11451, Riyadh, Saudi Arabia. rabdelgaber@ksu.edu.sa.ORCID http://orcid.org/0000-0001-9263-6871

Funding

Princess Nourah bint Abdulrahman University Researchers Supporting Project number, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. (PNURSP2026R931)
6 · The paper itself

Abstract

purposeCoccidiosis, a parasitic disease in animals, is often treated with coccidiostats, but their excessive use has led to drug resistance, reducing treatment efficacy. This study sought to investigate the in vitro and in vivo anticoccidial capacity of zinc oxide nanoparticles using Coriandrum sativum extract (CSE-ZnONPs) against Eimeria papillata.

methodsCSE-ZnONPs were synthesized and characterized via transmission electron microscopy (TEM) and energy dispersive X-ray spectroscopy (EDX). E. papillata oocysts were treated in vitro with decreasing selected concentrations from CSE-ZnONPs (100 - 0.5 mg/ml K

resultsIn vitro results indicated that CSE-ZnONPs markedly decreased sporulation rates and caused morphological damage in E. papillata oocysts. The in vivo oral administration of CSE-ZnONPs to infected mice considerably reduced the numbers of jejunal endogenous stages and notably decreased their morphometric dimensions. Immunohistochemistry demonstrated a downregulation of Cluster of Differentiation 4 (CD4) and Inducible Nitric Oxide Synthase (iNOS) expression, whereas biochemical antioxidant studies indicated reduced nitric oxide and malondialdehyde levels, alongside elevated superoxide dismutase and catalase activity. ELISA verified reduced serum concentrations of interferon-γ, tumor necrosis factor-α, interleukin-10, and iNOS in the treated mice.

conclusionCSE-ZnONPs possess a promising potent in vitro sporulation inhibition and in vivo anticoccidial, antioxidant, anti-inflammatory and immuno-therapeutic properties against E. papillata.

Indexed as

CoccidiosisCoccidiostatsEimeriaNanoparticlesZinc OxideAnimalsFemaleMiceMicroscopy, Electron, TransmissionOocystsPlant ExtractsCoccidiostatsPlant ExtractsZinc OxideCytokinesEimeria papillataOocystsOxidative stressSEMZinc oxide nanoparticles

Identifiers

PMID42154384

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.