Exploring Marine Polysaccharides from Uroteuthis duvauceli Gladius Waste: Structural Insights and Biofunctional Properties.

Marine ecosystems represent a significant source of bioactive compounds, with cephalopods such as Uroteuthis duvauceli demonstrating considerable therapeutic potential. In this study, marine polysaccharides were extracted from the gladius of U. duvauceli and characterized using Fourier Transform Infrared Spectroscopy (FTIR), Field Emission Scanning Electron Microscopy (FESEM), and X-Ray Diffraction (XRD). The polysaccharide demonstrated notable antioxidant activity, including a DPPH scavenging effect of 45.17% at 10 mg/ml, superoxide radical scavenging activity of 64.19% at 10 mg/ml, and chelating ability of 71.59% at 10 mg/ml. Furthermore, the polysaccharide exhibited antibacterial activity against Escherichia coli (15 ± 1.53 mm) and Staphylococcus aureus (10 ± 0.58 mm), as determined by agar diffusion assays. Anticoagulant efficacy was assessed using Activated Partial Thromboplastin Time (APTT) and Prothrombin Time (PT) assays, yielding an APTT of 112 ± 3.52 s and a PT of 74 ± 2.25 s. These results indicate that U. duvauceli polysaccharides possess significant antibacterial, antioxidant, and anticoagulant properties, underscoring their potential as natural bioactive agents for pharmaceutical development. Further research is required to clarify their mechanisms of action and assess in vivo efficacy.