Evidence map›Paper›PMID 42154296›Full record

ArticleMolecular genetics and genomics : MGG2026

Functional characterization and allele-specific RNA interference-based rescue of KCNH2 p.F68C variant associated with long QT syndrome.

Miao Zhao, Meng Han, Wenjuan Li, Zhijie Wang, Li Chen, Hanyu Zeng, Ziqi Zhou, Dongping Hu, Yu Cheng, Qing Wang and 1 more

Abstract read
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In one paragraph

Article in Molecular genetics and genomics : MGG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Miao Zhao *Department of Physiology, Wannan Medical College, Wuhu, P. R. China.ORCID http://orcid.org/0000-0002-0482-1426
Meng Han *Hubei Provincial Key Laboratory of Occurrence and Intervention of Kidney Diseases, Medical College, Hubei Polytechnic University, Huangshi, Hubei, P. R. China.ORCID http://orcid.org/0000-0001-8096-3859
Wenjuan Li *Department of Quality Control, Chongqing Yaoyou Pharmaceutical Limited Liability Company, Chongqing, P. R. China.
Zhijie Wang *Department of Gynecology Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Li ChenCollege of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei Province, P. R. China.
Hanyu ZengDepartment of Physiology, Wannan Medical College, Wuhu, P. R. China.
Ziqi ZhouCollege of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei Province, P. R. China.
Dongping HuCollege of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei Province, P. R. China.
Yu ChengCollege of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei Province, P. R. China.
Qing WangCollege of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei Province, P. R. China. qingwang118@qq.com.ORCID http://orcid.org/0000-0002-2235-6572
Tie KeCollege of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei Province, P. R. China. ket@hust.edu.cn.ORCID http://orcid.org/0000-0002-8888-8424

Funding

Doctoral Scientific Research Foundation of Wannan Medical College WYRCQD20230012National Key R&D Program of China 2023YFA1800900Natural Science Foundation of Hubei Province 2022CFB996
6 · The paper itself

Abstract

Long QT syndrome (LQTS) is an inherited life-threatening cardiac disorder characterized by delayed ventricular repolarization and increased risk of malignant arrhythmias. Among its subtypes, long QT syndrome type 2 (LQT2) is primarily caused by pathogenic variants in KCNH2, which encodes the human ether-à-go-go-related gene (hERG) potassium channel responsible for the rapid delayed rectifier current (I

Indexed as

ERG1 Potassium ChannelLong QT SyndromeAllelesFemaleHEK293 CellsHumansMaleRNA InterferenceERG1 Potassium ChannelKCNH2 protein, humanHERGKCNH2Long QT syndromeRNA interferenceVariant

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.