Evidence map›Paper›PMID 42154236›Full record

ArticleCellular and molecular life sciences : CMLS2026

Cdk7 promotes neuritogenesis in cortical neurons and contributes to social behavior in mice.

Sébastien Verteneuil, Laura Van Hees, Jean-Marc Lassance, Camille Lejon, Tine D'aes, Quentin Marlier, Pascale Quatresooz, Laurence Delacroix, Laurent Nguyen, Brigitte Malgrange and 1 more

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In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sébastien VerteneuilLaboratory of Developmental Neurobiology, GIGA Institute, University of Liège, Liège, 4000, Belgium.
Laura Van HeesLaboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, 4000, Belgium.
Jean-Marc LassanceLaboratory of Evolutionary Neuroethology, GIGA Institute, University of Liège, Liège, 4000, Belgium.
Camille LejonLaboratory of Developmental Neurobiology, GIGA Institute, University of Liège, Liège, 4000, Belgium.
Tine D'aesLaboratory of Developmental Neurobiology, GIGA Institute, University of Liège, Liège, 4000, Belgium.
Quentin MarlierLaboratory of Developmental Neurobiology, GIGA Institute, University of Liège, Liège, 4000, Belgium.
Pascale QuatresoozDivision of Histology, Department of Biomedical and Preclinical Sciences, University of Liège, Liège, 4000, Belgium.
Laurence DelacroixLaboratory of Developmental Neurobiology, GIGA Institute, University of Liège, Liège, 4000, Belgium.
Laurent NguyenLaboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège, 4000, Belgium.
Brigitte Malgrange *Laboratory of Developmental Neurobiology, GIGA Institute, University of Liège, Liège, 4000, Belgium. bmalgrange@uliege.be.ORCID http://orcid.org/0000-0002-8957-2528
Renaud Vandenbosch *Laboratory of Developmental Neurobiology, GIGA Institute, University of Liège, Liège, 4000, Belgium. rvandenbosch@uliege.be.ORCID http://orcid.org/0000-0003-4887-9870

Funding

Fonds De La Recherche Scientifique - FNRS R.FNRS.4347Fonds De La Recherche Scientifique - FNRS R.FNRS.4918Fonds Léon Fredericq FLF005Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture ASP-001
6 · The paper itself

Abstract

Cyclin-dependent kinase 7 (Cdk7) is a unique Cdk that drives cell proliferation and gene transcription. While its involvement in dividing cells as a Cdk-activating kinase (CAK) is essential for cell cycle progression, its function during the differentiation of postmitotic cells remains to be elucidated. Here, we show that loss of Cdk7 in developing cortical neurons critically hampers neurite growth and leads to aberrant social behaviors. Mechanistically, transcriptomic analysis reveals that the lack of Cdk7 in cortical neurons results in the downregulation of numerous genes controlling neuronal morphology, including several key players in the Calcium-dependent Wnt5a pathway. Interestingly, supplementing Cdk7-cKO neurons with Wnt5a ligand partially mitigates the observed defects in neuritogenesis. Our work highlights the importance of transcriptional Cdks beyond cell cycle exit and underscores their critical importance for normal brain function.

Indexed as

Cerebral CortexCyclin-Dependent KinasesNeuritesNeurogenesisNeuronsSocial BehaviorAnimalsCells, CulturedCyclin-Dependent Kinase-Activating KinaseMiceMice, KnockoutNeurodevelopmentWnt-5a ProteinCyclin-Dependent Kinase-Activating KinaseCyclin-Dependent KinasesWnt-5a ProteinWnt5a protein, mouseCdksCortical NeuronsNeuronal morphology

Identifiers

PMID42154236
PMCPMC13350628

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.