Observational studySleep & breathing = Schlaf & Atmung2026
Polysomnographic findings and brain maturation in infants with Prader-Willi syndrome: a retrospective observational study.
Observational study in Sleep & breathing = Schlaf & Atmung, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePrader-Willi syndrome (PWS) is a rare genetic disorder characterized by hypothalamic dysfunction and brainstem immaturity, contributing to central sleep apnea (CSA), hypoventilation and hypersomnolence. Obstructive sleep apnea (OSA) is more common in older children with PWS due to adenotonsillar hypertrophy and obesity. Data on polysomnographic findings in infants remain scarce. This study aimed to assess sleep-disordered breathing and its possible association with brain maturation, based on electroencephalography (EEG) findings, in infants (< 12 months) with PWS.
methodsWe conducted a retrospective analysis of polysomnography (PSG) and EEG data, from seven growth hormone-naive infants with PWS. Statistical comparisons were made between neonatal and older infants, and between those with age-appropriate versus dysmature EEGs.
resultsOne infant died suddenly and unexpectedly before PSG could be completed. The median central apnea index was 1.42/h; none of the infants met criteria for CSA. OSA was present in 66.6% of PSGs, with a median obstructive apnea-hypopnea index of 3.94/h. All infants had low arousal indices. Delayed brain maturation was observed in three infants on EEG, with no correlation found between EEG maturity and apnea indices.
conclusionOSA also presents in infants with PWS and is mainly caused by hypotonia and a narrow oropharynx. No correlation was found between EEG-based brain immaturity and central apnea severity. Given the respiratory vulnerability of these infants, a baseline PSG is strongly recommended. Larger studies are needed to confirm these findings and to clarify their clinical implications, including the potential role of EEG in early risk stratification.
Indexed as
Identifiers
42154139What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.