ReviewActa parasitologica2026
Genital Dirofilaria: A Comprehensive Review of Clinical Presentations, Diagnosis and Management.
Review in Acta parasitologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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0 citing papers in PubMed.
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHuman dirofilariasis, an emerging mosquito-borne zoonosis, is increasing, particularly in Europe. While subcutaneous presentations are the most common infections, genital presentations are rare and can pose significant diagnostic challenges. PURPOSE: This review aims to provide an updated synthesis of all detailed published cases of genital dirofilariasis analyzing clinical characteristics, diagnostic methods, treatment strategies, and epidemiological implications to enhance clinical awareness and management.
methodsA comprehensive literature review was conducted to identify cases of Dirofilaria species with genital involvement in databases such as PubMed, Scopus, Web of Science and Google Scholar and through manual searches.
resultsGenital dirofilariasis is a rare condition, with 70 detailed documented cases identified in this review, representing the largest collection published to date. Dirofilaria repens is the predominant cause. Clinical presentation is often non-specific mimicking common or threatening conditions such as orchiepididymitis, spermatic cord torsion or undiagnosed nodule. The condition affects all ages, with a notable 40% of cases occurring in the pediatric population, particularly in Sri Lanka. Definitive diagnosis typically requires surgical excision and expert histopathological examination, supported by molecular techniques for species identification, if available and certificated. Imaging, mainly ultrasound, may reveal the highly suggestive "worm-in-sac sign". Minimally invasive excisional surgery is generally curative and post-operative antiparasitic therapy is usually not required after complete excision.
conclusionsGenital dirofilariasis should be included in the differential diagnosis of unexplained genital nodules or masses, especially in endemic areas or in patients with a history of travel to such regions. The diagnostic and therapeutic approach proposed here helps in identifying and managing these peculiar parasitic infections. A multidisciplinary approach is essential to avoid misdiagnosis and inappropriate invasive interventions.
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