Evidence map›Paper›PMID 42154098›Full record

ArticleFish physiology and biochemistry2026

A lansoprazole-like structure derived from Streptomyces metabolites: evaluation of its protective effects on hepatorenal function, antioxidant activity, and immune parameters in African catfish challenged with Staphylococcus aureus.

Rewan Abdelaziz, Saeedah M Almutairi, Mohamed R AbdelGawwad, Kasim Sakran Abass, Sheeren Abdelaziz, Azza SalahEldin El-Demerdash, Riyadh Alotaibi, Mohamed Taha Yassin

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Article in Fish physiology and biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Rewan AbdelazizDepartment of Microbiology, Faculty of Science, Ain Shams University, Cairo, 11517, Egypt. rewan_abdelaziz92@yahoo.com.
Saeedah M AlmutairiDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Mohamed R AbdelGawwadGenetics and Bioengineering Department, Faculty of Engineering and Natural Sciences, International University of Sarajevo, Sarajevo, 71210, Bosnia and Herzegovina.
Kasim Sakran AbassDepartment of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Kirkuk, Kirkuk, 36001, Iraq.
Sheeren AbdelazizDepartment of Microbiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt.
Azza SalahEldin El-DemerdashInstitution and Department, Department of Biotechnology, Animal Health Research Institute, Zagazig, 44511, Egypt.
Riyadh AlotaibiDivision of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK.
Mohamed Taha YassinDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated the antibacterial potential of a novel metabolite, a lansoprazole-like structure (LPZS), derived from the marine actinomycete Streptomyces huiliensis (PQ285591) against Staphylococcus aureus (MSSA). Out of 30 marine isolates from the Mediterranean Sea, S. huiliensis exhibited the most potent bioactivity. The purified metabolite, identified via NMR, TLC, HPLC, and GC-MS, demonstrated a significant minimum inhibitory concentration (MIC) of 0.5 μg/mL against S. aureus in vitro. The in vivo efficacy and safety were assessed using 120 African catfish (Clarias gariepinus) challenged with S. aureus (1.6 × 10⁶ CFU/mL). Treatment with LPZS (100 μg/mL) significantly (p < 0.05) mitigated infection-induced mortality and clinical symptoms. Furthermore, LPZS administration improved hepatorenal biomarkers, enhanced nonspecific immune responses (lysozyme and nitric oxide), and bolstered antioxidant capacity. Histopathological examination confirmed that LPZS effectively reversed tissue damage in the liver, kidney, and spleen. These findings suggest that LPZS is a safe and potent antibacterial agent, offering a promising therapeutic alternative for managing staphylococcal infections in aquaculture.

Indexed as

Anti-Bacterial AgentsCatfishesFish DiseasesLansoprazoleStaphylococcal InfectionsStreptomycesAnimalsAntioxidantsKidneyLiverNitric OxideStaphylococcus aureusAnti-Bacterial AgentsAntioxidantsLansoprazoleNitric OxideAfrican catfishLansoprazole-like structureStaphylococcus aureusStreptomyces huiliensis

Identifiers

PMID42154098

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