ArticleApplied microbiology and biotechnology2026
LysR-type transcriptional regulator TtdR regulates both ethylene glycol and polyhydroxyalkanoate (PHA) metabolism in Pseudomonas umsongensis GO16.
Article in Applied microbiology and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Pseudomonas umsongensis GO16, a LysR-type transcriptional regulator (LTTRs) ttdR is located 5' of the gene for glyoxylate carboligase (gcl), involved in ethylene glycol (EG) metabolism. GO16 wildtype (WT) can utilize EG as a sole carbon and energy source but the ttdR knockout strain (ΔttdR) cannot grow on EG, demonstrating its role as an activator in EG metabolism. When ΔttdR was grown with terephthalic acid (TA) or glucose, the growth was comparable to the WT. GO16 originally produces both C4 short-chain-length (scl) PHA and C6-C12 medium-chain-length (mcl) PHA from various carbon sources. Interestingly, ΔttdR produced scl-PHA monomer 5.4-fold and 1.4-fold increased than the WT when TA and glucose were used respectively. Furthermore, ΔttdR exhibited a very long lag phase when grown with fatty acids, namely butyrate or octanoate. This indicates a more complex role of TtdR than simply activating EG metabolism in GO16. The analysis of the GO16 ΔttdR proteome revealed that EG catabolic genes were expressed, but their abundance was 2.8- to 10.5-fold lower (log
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.