Evidence map›Paper›PMID 42154011›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Synthesis, computational studies, and biological evaluation of novel cyanoacrylamides as potential anticancer agents.

Marwa H Soliman, Karim Barakat, Ismail A Abdelhamid, Mona H Mohamed, Emad M Elzayat, Abdelhady A Abdelwahab, Yasmin M Attia, Mohamed A Ragheb

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marwa H SolimanDepartment of Chemistry (Biochemistry Division), Faculty of Science, Cairo University, Giza, 12613, Egypt.
Karim BarakatDepartment of Chemistry (Biochemistry Division), Faculty of Science, Cairo University, Giza, 12613, Egypt.
Ismail A AbdelhamidDepartment of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt. ismail_shafy@yahoo.com.ORCID http://orcid.org/0000-0003-1220-8370
Mona H MohamedDepartment of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Emad M ElzayatBiotechnology Department, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Abdelhady A AbdelwahabDepartment of Cancer Biology, National Cancer Institute, Cairo University, Cairo, Egypt.
Yasmin M AttiaDepartment of Cancer Biology, National Cancer Institute, Cairo University, Cairo, Egypt.
Mohamed A RaghebDepartment of Chemistry (Biochemistry Division), Faculty of Science, Cairo University, Giza, 12613, Egypt. mattia@cu.edu.eg.ORCID http://orcid.org/0000-0003-1244-1156

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel series of cyanoacrylamides based on thiazole was synthesized and characterized by different physicochemical and multispectral investigations. The new compounds have been assessed for their cytotoxic potential against several human cancer cell lines (HCT-116, MCF-7, HEp-2, and WI-38). Compound 5g, incorporating 4-(piperidin-1-yl)phenyl moiety, was selected as it emerged to achieve the potent cytotoxic effect against HCT-116 and MCF-7 cell lines, with IC

Indexed as

AcrylamidesAntineoplastic AgentsApoptosisCell CycleCell Line, TumorHCT116 CellsHumansMCF-7 CellsMolecular Docking SimulationStructure-Activity RelationshipAcrylamidesAntineoplastic AgentsADMET, Molecular dockingApoptosisCell cycle arrestCyanoacrylamidesCytotoxicity

Identifiers

PMID42154011

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.