ArticleJournal of child neurology2026
Evaluating Associations Between Postconcussion Physical Activity and Brain Neurometabolite Concentrations in the Posterior Cingulate Gyrus.
Article in Journal of child neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
ObjectiveTo examine the association between brain neurometabolite concentrations and physical activity (PA) volume after adolescent concussion.MethodsWe performed a longitudinal study of adolescents (13-18 years) with concussion. At an initial visit (visit 1; within 21 days of injury), participants rated their symptoms using the Post-Concussion Symptom Inventory (PCSI) and underwent magnetic resonance spectroscopy (MRS) to quantify neurometabolite concentrations in the posterior cingulate gyrus (PCG). Metabolites of interest were glutathione (GSH), glutamate-glutamine (Glx), total choline (tCho), and myo-inositol (mI). Following visit 1, participants were provided with wrist-worn activity monitors for the subsequent 14 days to track steps/day. They repeated MRS evaluation within 5 days of receiving medical clearance to return to sports (visit 2). We compared neurometabolite concentrations between visits, then used linear regression to investigate how PA was associated with neurometabolite concentrations at each visit independently.ResultsTwenty-seven adolescents underwent MRS scans (15.8 ± 1.3 years; 56% female; assessed 11.7 ± 4.2 and 37.3 ± 16.1 days postinjury) and n = 16 completed PA monitoring. Neurometabolite concentrations did not differ between visits 1 and 2 (
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