Evidence map›Paper›PMID 42153785›Full record

ArticleInvestigative ophthalmology & visual science2026

Initial Site of Macular Involvement in Central Retinal Dystrophies Revealed by Fundus Autofluorescence and Optical Coherence Tomography.

Hirohiko Kawashima, Kei Mizobuchi, Takaaki Hayashi, Taro Kominami, Koji M Nishiguchi, Shinji Ueno, Go Mawatari, Yasuhiro Ikeda, Mineo Kondo, Tetsuju Sekiryu and 5 more

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Article in Investigative ophthalmology & visual science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Hirohiko KawashimaDivision of Vision Research, National Institute of Sensory Organs, NHO Tokyo Medical Center, Tokyo, Japan.
Kei MizobuchiDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.
Takaaki HayashiDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.
Taro KominamiDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, Aichi, Japan.
Koji M NishiguchiDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, Aichi, Japan.
Shinji UenoDepartment of Ophthalmology, Hirosaki University Graduate School of Medicine, Aomori, Japan.
Go MawatariDepartment of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Yasuhiro IkedaDepartment of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Mineo KondoDepartment of Ophthalmology, Mie University Graduate School of Medicine, Mie, Japan.
Tetsuju SekiryuDepartment of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Sentaro KusuharaDivision of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Makoto NakamuraDivision of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Kaoru FujinamiDivision of Vision Research, National Institute of Sensory Organs, NHO Tokyo Medical Center, Tokyo, Japan.
Takeshi IwataDivision of Molecular and Cellular Biology, National Institute of Sensory Organs, NHO Tokyo Medical Center, Tokyo, Japan.
Kazushige TsunodaDivision of Vision Research, National Institute of Sensory Organs, NHO Tokyo Medical Center, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To determine the site of the initial alterations in the macula region in patients with central retinal dystrophies. Methods: Two hundred nine Japanese patients who were clinically or genetically diagnosed with central retinal dystrophies were retrospectively studied. The center of the small definitely decreased autofluorescence (DDAF) site in the fundus autofluorescence images that initially appeared in the macular region was defined as the site of the primary lesion of the retinal pigment epithelial (RPE) layer. The center of the ellipsoid zone (EZ) defect that initially appeared in the optical coherence tomographic images was defined as the site of the primary lesion of the photoreceptor layer. Results: The site of the primary lesion in the RPE layer was identified in 18 right eyes and 16 left eyes. The mean ± SD distance of these sites from the foveal center was 847.3 ± 233.4 µm in the right eye and 850.6 ± 144.3 µm in the left eye. The primary site of the lesion in the photoreceptor layer was identified in 16 of 342 eyes, and the mean ± SD distance from the foveal center was 847.4 ± 158.0 µm. 82.4% of the initial RPE lesion sites and 93.8% of the initial EZ lesion sites were located between 500 and 1,000 µm from the foveal center. We have named this region the parafoveal fragile zone (PFZ). Conclusions: The presence of a PFZ in eyes with central retinal dystrophies is most likely related to the unique anatomic and physiological characteristics of the macular region.

Indexed as

Fluorescein AngiographyMacula LuteaRetinal DystrophiesRetinal Pigment EpitheliumTomography, Optical CoherenceAdolescentAdultAgedChildFemaleFundus OculiHumansMaleMiddle AgedRetrospective StudiesYoung Adult

Identifiers

PMID42153785
PMCPMC13206804

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