Evidence map›Paper›PMID 42153761›Full record

ArticleEuropean stroke journal2026

Enhancing stroke care in Europe: cost-effectiveness analysis of strategies addressing gaps in acute ischemic stroke care.

Bianca de Greef, Ji-Hee Youn, Henri V Bavière, Marjan Hummel, Angelique Balguid, Francesca Pezzella, Hanne Christensen, Wim van Zwam

Abstract read
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Article in European stroke journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bianca de GreefChief Medical Office, Health Economics and Outcomes Research, Philips, Amsterdam, the Netherlands.
Ji-Hee YounChief Medical Office, Health Economics and Outcomes Research, Philips, Amsterdam, the Netherlands.ORCID 0000-0003-1382-495X
Henri V BavièreChief Medical Office, Health Economics and Outcomes Research, Philips, Amsterdam, the Netherlands.
Marjan HummelChief Medical Office, Health Economics and Outcomes Research, Philips, Amsterdam, the Netherlands.
Angelique BalguidImage-Guided Therapy Systems, Philips, Best, the Netherlands.
Francesca PezzellaStroke Unit, Department of Neuroscience, S Camillo Forlanini Hospital, Rome, Italy.ORCID 0000-0002-5902-2795
Hanne ChristensenDepartment of Neurology, Copenhagen University Hospital, Bispebjerg, Denmark.ORCID 0000-0002-7472-3194
Wim van ZwamDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Center+, Maastricht, the Netherlands.ORCID 0000-0003-1631-7056

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAcute ischemic stroke (AIS) is a leading cause of disability and mortality worldwide, resulting in a significant economic burden. The European Stroke Action Plan set targets to improve stroke care, but substantial variation persists across countries. PATIENTS AND

methodsA decision-analytic model was developed. By comparing baseline performance in stroke care, based on data from 2015 to 2020, with the performance when meeting targets set on incidence, time and access to treatment and prevention, we estimated the potential clinical and economic impact in 7 European countries. The primary outcome was the incremental cost-effectiveness ratio, based on costs and quality-adjusted life-years (QALYs); secondary outcomes included disability (modified Rankin Scale; mRS).

resultsAchieving the targets produced meaningful health gains in all countries, with several scenarios being dominant. Reducing stroke incidence had the greatest overall impact. Among the remaining targets, shorter time to treatment was dominant in France, Italy and the United Kingdom, and consistently reduced disability across countries (0.9%-14.3% point decreases in patients with mRS 3-5). Increasing endovascular treatment rates showed the greatest effect in Sweden and Spain and remained cost-effective elsewhere (€1823-€5331 per QALY gained). Reducing recurrent stroke delivered the largest cost savings in the Netherlands and the United Kingdom (€436 and €483 per patient, respectively) whilst generating QALY gains.

conclusionAlthough reducing stroke incidence yields the greatest overall benefit, optimal strategies differ between countries. Tailored approaches addressing country-specific care gaps will be essential to maximise health gains, reduce disability and improve economic efficiency of stroke care.

Indexed as

Brain IschemiaCost-Benefit AnalysisCost-Effectiveness AnalysisIschemic StrokeStrokeEuropeFemaleHumansMaleQuality-Adjusted Life Yearsacute ischaemic strokecost-effectiveness analysisdecision-analytic modelling

Identifiers

PMID42153761
PMCPMC13184963

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.