Early treatment of Atrial fibrillation for Stroke prevention Trial in acute STROKE (EAST-STROKE): protocol for an international investigator-initiated, prospective, randomised, open, blinded endpoint assessment (PROBE) interventional multi-centre trial.
Article in European stroke journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05293080 (Early Treatment of Atrial Fibrillation for Stroke Prevention Trial in Acute STROKE), which is not on this map. Not yet cited in PubMed.
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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Treatment of Atrial Fibrillation for Stroke Prevention Trial in Acute STROKE
TypeinterventionalSponsorUniversitätsklinikum Hamburg-EppendorfRan2025 to 2031Enrolled1,746ConditionsAcute Ischemic Stroke, Atrial FibrillationArmsMedical or interventional therapy for rhythm control in atrial fibrillation (antiarrhythmic drugs, ablation, electric cardio version), Usual care for atrial fibrillation
3 · Its place in the literature
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The record
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
25 authors.
Märit JensenDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.ORCID 0000-0001-7793-0941
Antonia ZapfInstitute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-8467-0508
Anika BuchholzInstitute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-6390-1573
Annika MöhlInstitute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0003-3274-7216
Jason G AndradeVancouver General Hospital, Vancouver, British Columbia, Canada.ORCID 0000-0002-8493-5123
Alan CameronSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0001-6965-1109
Bruce C V CampbellDepartment of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.ORCID 0000-0003-3632-9433
Michael D HillDepartment of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0002-6269-1543
Peter KellyStroke Clinical Trials Network Ireland and School of Medicine, University College Dublin, Dublin, Ireland.ORCID 0000-0003-4772-6565
Jonathan M KalmanDepartment of Cardiology, The Royal Melbourne Hospital, Melbourne, Australia.ORCID 0000-0002-6618-7184
Peter LohDepartment of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands.ORCID 0000-0002-3263-9007
Carlos MolinaStroke Unit, Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain.ORCID 0000-0001-6058-6259
Eduard GuaschCardiology Department, Hospital Clinic Barcelona, Barcelona, Catalonia, Spain.ORCID 0000-0003-4238-5319
Andreas MetznerGerman Centre for Cardiovascular Research (DZHK e.V.), Hamburg/Kiel/Lübeck, Germany.ORCID 0000-0002-6818-6396
G André NgDivision of Cardiovascular Sciences, British Heart Foundation Leicester Centre of Research Excellence, University of Leicester, National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom.ORCID 0000-0001-5965-0671
Jorge PagolaStroke Unit, Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain.ORCID 0000-0002-0725-1369
Octávio M Pontes-NetoStroke Service, Neurology Division, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.ORCID 0000-0003-0317-843X
Tobias ReichlinDepartment of Cardiology, Inselspital Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0002-7197-8415
Rustam Al-Shahi SalmanInstitute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0002-2108-9222
Ashkan ShoamaneshDivision of Neurology, Department of Medicine, Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-2802-1626
Luciano A SposatoDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.ORCID 0000-0001-6425-9343
H Bart van der WorpDepartment of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID 0000-0001-9891-2136
Paulus KirchhofGerman Centre for Cardiovascular Research (DZHK e.V.), Hamburg/Kiel/Lübeck, Germany.ORCID 0000-0002-1881-0197
Götz ThomallaDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.ORCID 0000-0002-4785-1449
Funding
2022 Medical Research Future Fund (MRFF) International Clinical Trial Collaborations Round 2 2025554CIHR 550601EAST-STROKE is an investigator-initiated clinical trialEuropean Union as a collaborative project within HORIZON-HLTH-2024-DISEASE-03-two-stage 101156541German Research Foundation 535121142National Health and Medical Research CouncilState Secretariat for Education, Research and InnovationUniversity Medical Center Hamburg-Eppendorf
6 · The paper itself
Abstract
backgroundAcute ischaemic stroke patients with atrial fibrillation (AF) are at high risk of suffering a recurrent stroke or other cardiovascular complications. It is uncertain whether early rhythm-control therapy is effective and safe in preventing recurrent strokes and cardiovascular complications in these patients. STUDY
designEarly treatment of Atrial fibrillation for Stroke prevention Trial in acute STROKE (EAST-STROKE) is an international investigator-initiated, prospective, randomised, open, blinded endpoint assessment (PROBE) interventional multi-centre trial. Patients with acute ischaemic stroke and AF will be randomised within 4 weeks of stroke (1:1) to receive either early rhythm control and usual care or usual care alone. Usual care includes oral anticoagulation, rate control and treatment of cardiovascular conditions. Early rhythm control additionally comprises treatment with antiarrhythmic drugs, AF ablation or cardioversion. A minimum of 1746 participants will be randomised to observe 351 events. The adaptive design includes one interim analysis with sample size re-estimation after 50% of events. STUDY ENDPOINTS: The primary outcome is a composite of first recurrent ischaemic stroke, haemorrhagic stroke, unclassified stroke, cardiovascular death or hospitalisation due to worsening of heart failure or due to acute coronary syndrome, analysed as time to the first occurrence. Secondary outcomes include individual components of the primary outcome, functional status and patient-reported outcome measures. Safety outcomes comprise all-cause mortality and adverse events. Patients will be followed-up until the end of the trial with a minimum follow-up period of 24 months and an expected mean follow-up period of 42 months. SUMMARY: EAST-STROKE will determine whether early rhythm-control therapy in addition to usual care is effective and safe in patients with acute ischaemic stroke and AF.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Early treatment of Atrial fibrillation for Stroke prevention Trial in acute STROKE (EAST-STROKE): protocol for an international investigator-initiated, prospective, randomised, open, blinded endpoint assessment (PROBE) interventional multi-centre trial. · full record | OpenQuestion