ArticleAge and ageing2026
Multimorbidity patterns and hospitalizations due to lower respiratory tract infections: a 15-year population-based cohort study.
Article in Age and ageing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
backgroundLower respiratory tract infections (LRTIs) are common among older adults and are associated with high healthcare utilization, particularly in those with multimorbidity (≥2 chronic conditions). We aimed to investigate the association between different multimorbidity patterns and LRTI-related hospitalizations. MATERIALS AND
methodsWe used data from the population-based Swedish National study on Aging and Care in Kungsholmen (SNAC-K). Latent class analysis was applied to participants with multimorbidity to identify multimorbidity patterns. A disease was considered to characterize a pattern if exclusivity was ≥25% or the observed/expected ratio was ≥2. Cox regressions were used to estimate hazard ratios (HRs) for the association between multimorbidity patterns and [1] LRTI-related hospitalizations and [2] all-cause 30-day readmission, compared with participants without multimorbidity.
resultsAmong the 3301 study participants, 2931 (87.5%) had multimorbidity, and over a median follow-up of 14 years, 412 (12.5%) were hospitalized with an LRTI and 152 (4.5%) experienced a 30-day readmission. Five multimorbidity patterns were identified. The cardiometabolic pattern showed the highest hazards for LRTI-related hospitalizations and 30-day readmissions, followed by the psychiatric/respiratory pattern. The neuropsychiatric pattern was associated with increased hazard of 30-day readmissions.
conclusionsMultimorbidity patterns are differentially associated with LRTI-related hospitalizations and 30-day readmissions, suggesting that the link between LRTIs and multimorbidity patterns is complex and reflects the specific burden of diverse multimorbidity patterns.
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