Evidence map›Paper›PMID 42153646›Full record

ArticlemSphere2026

Gut Hi-C metagenomes of severe COVID-19 patients: bacteria and yeast involved in gut-lung axis.

Anastasia Z Revel-Muroz, Ignat V Sonets, Alexander S Chistyakov, Petr A Vasiluev, Yury A Surovoy, Valeriia A Ivanova, Liubov I Kozlovskaya, Olga E Khokhlova, Mikhail V Fursov, Nadezhda K Fursova and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anastasia Z Revel-MurozInstitute of Gene Biology Russian Academy of Sciences, Moscow, Russia.ORCID 0000-0002-6517-1375
Ignat V SonetsInstitute of Gene Biology Russian Academy of Sciences, Moscow, Russia.ORCID 0009-0009-7266-6657
Alexander S ChistyakovInstitute of Gene Biology Russian Academy of Sciences, Moscow, Russia.
Petr A VasiluevInstitute of Gene Biology Russian Academy of Sciences, Moscow, Russia.
Yury A SurovoyI.I. Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.
Valeriia A IvanovaInstitute of Gene Biology Russian Academy of Sciences, Moscow, Russia.
Liubov I KozlovskayaFSASI Chumakov FSC R&D IBP RAS (Institute of Poliomyelitis), Moscow, Russia.
Olga E KhokhlovaState Research Center for Applied Microbiology and Biotechnology, Obolensk, Russia.
Mikhail V FursovState Research Center for Applied Microbiology and Biotechnology, Obolensk, Russia.
Nadezhda K FursovaState Research Center for Applied Microbiology and Biotechnology, Obolensk, Russia.ORCID 0000-0001-6053-2621
Sergey V UlianovInstitute of Gene Biology Russian Academy of Sciences, Moscow, Russia.
Alexander V TyakhtInstitute of Gene Biology Russian Academy of Sciences, Moscow, Russia.ORCID 0000-0002-7358-2537

Funding

Ministry of Science and Higher Education of the Russian Federation 075-15-2025-475
6 · The paper itself

Abstract

Antimicrobial resistance (AMR) poses a critical threat to global health, particularly in intensive care units, where vulnerable patients are frequently exposed to multidrug-resistant microorganisms. The human gut microbiome serves as a key reservoir for AMR genes, which can disseminate to other body sites, including the lungs, especially during severe illness. We applied Hi-C metagenomics to stool samples from 11 critically ill COVID-19 patients and analyzed microbial isolates from their lungs to investigate intra-host transmission of AMR genes. Plasmid-resolved microbial interaction networks revealed AMR gene sharing across 13 bacterial genera, primarily from Firmicutes and Proteobacteria, with evidence of plasmid-mediated transfer across phylum boundaries and between gut and lung compartments. Notably, we identified genetically identical

Indexed as

BacteriaCOVID-19Gastrointestinal MicrobiomeLungMetagenomeAgedCandidaFecesFemaleHumansKlebsiella pneumoniaeMaleMetagenomicsMiddle AgedPandemicsPlasmidsCandidaCOVID-19drug resistancegut-lung axisgut microbiomeHi-C metagenomicsICUKlebsiellaplasmid transfer

Identifiers

PMID42153646
PMCPMC13317233

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.