Evidence map›Paper›PMID 42153573›Full record

ArticleAutophagy2026

Feedback loops between DNMT1 and autophagy as well as senescence promotes organ aging and canities.

Lu Li, Xinyue Mao, Linda Xiaoyan Li, Huaping Xiao, Zhenkun Lou, Hongbo Liu, Julie Xia Zhou, Li Yao, Xiaogang Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lu LiDepartment of Medicine, Mayo Clinic, Rochester, MN, USA.
Xinyue MaoDepartment of Medicine, Mayo Clinic, Rochester, MN, USA.
Linda Xiaoyan LiDepartment of Medicine, Mayo Clinic, Rochester, MN, USA.
Huaping XiaoDepartment of Oncology, Mayo Clinic, Rochester, MN, USA.
Zhenkun LouDepartment of Oncology, Mayo Clinic, Rochester, MN, USA.
Hongbo LiuDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.
Julie Xia ZhouDepartment of Medicine, Mayo Clinic, Rochester, MN, USA.
Li YaoDepartment of Nephrology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Xiaogang LiDepartment of Medicine, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-8135-342X

Funding

The crosstalk of DNA and lysine methyltransferases in ADPKD.R01DK126662 · NIDDK · MAYO CLINIC ROCHESTER · PI Xiaogang Li · 2020 to 2026
$3.0M
ADPKD: Understanding immunosuppression mechanisms and discovering treatmentR01DK129241 · NIDDK · MAYO CLINIC ROCHESTER · PI LI, XIAOGANG · 2021 to 2024
$1.8M
NIDDK NIH HHS R01 DK126662NIDDK NIH HHS R01 DK129241
6 · The paper itself

Abstract

Alternations of DNA methylation occur in aging, which is regulated by DNA methyltransferases (DNMTs). In this study, we show that even though the transcription of DNMT1, the only enzyme that maintains DNA methylation in the mammalian genome, is reported to be decreased in an age-dependent manner, the decrease of

Indexed as

AgingAutophagyDNA (Cytosine-5-)-Methyltransferase 1Feedback, PhysiologicalHair FollicleMelaninsAnimalsAutophagy-Related Protein 7DNA MethylationHumansMiceAtg7 protein, mouseAutophagy-Related Protein 7DNA (Cytosine-5-)-Methyltransferase 1Dnmt1 protein, mouseMelaninsATG7DNA methylationhair grayinglong-livedmelanin synthesissenolytics

Identifiers

PMID42153573
PMCPMC13618851

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.